The mutational spectrum of single base-pair substitutions causing human genetic disease: patterns and predictions
DN Cooper, M Krawczak - Human genetics, 1990 - Springer
Reports of single base-pair substitutions that cause human genetic disease and that have
been located and characterized in an unbiased fashion were collated; 32% of point …
been located and characterized in an unbiased fashion were collated; 32% of point …
Genetic instability in cancer: theory and experiment
RA Beckman, LA Loeb - Seminars in cancer biology, 2005 - Elsevier
Epidemiologic data and molecular biology have combined to demonstrate that multiple
genetic changes may be required in carcinogenesis. Mutator mutations, defined as genetic …
genetic changes may be required in carcinogenesis. Mutator mutations, defined as genetic …
The accuracy of reverse transcriptase from HIV-1
JD Roberts, K Bebenek, TA Kunkel - Science, 1988 - science.org
A study was conducted to determine the fidelity of DNA synthesis catalyzed in vitro by the
reverse transcriptase from a human immunodeficiency virus type 1 (HIV-1). Like other …
reverse transcriptase from a human immunodeficiency virus type 1 (HIV-1). Like other …
Fidelity of HIV-1 reverse transcriptase
BD Preston, BJ Poiesz, LA Loeb - Science, 1988 - science.org
The human immunodeficiency virus type 1 (HIV-1) shows extensive genetic variation and
undergoes rapid evolution. The fidelity of purified HIV-1 reverse transcriptase was measured …
undergoes rapid evolution. The fidelity of purified HIV-1 reverse transcriptase was measured …
Lack of evidence for proofreading mechanisms associated with an RNA virus polymerase
DA Steinhauer, E Domingo, JJ Holland - Gene, 1992 - Elsevier
The in vitro fidelity of the virion-associated RNA polymerase of vesicular stomatitis virus was
quantitated for a single conserved viral RNA site and the usual high in vitro base …
quantitated for a single conserved viral RNA site and the usual high in vitro base …
Orthogonality in organic, polymer, and supramolecular chemistry: from Merrifield to click chemistry
CH Wong, SC Zimmerman - Chemical Communications, 2013 - pubs.rsc.org
The concept of orthogonality has been applied to many areas of chemistry, ranging from
wave functions to chromatography. But it was Barany and Merrifield's orthogonal protecting …
wave functions to chromatography. But it was Barany and Merrifield's orthogonal protecting …
Rapid evolution of pandemic noroviruses of the GII. 4 lineage
Over the last fifteen years there have been five pandemics of norovirus (NoV) associated
gastroenteritis, and the period of stasis between each pandemic has been progressively …
gastroenteritis, and the period of stasis between each pandemic has been progressively …
Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity
RD Kuchta, P Benkovic, SJ Benkovic - Biochemistry, 1988 - ACS Publications
Department of Chemistry, 152 Davey Laboratory, The Pennsylvania State University,
University Park, Pennsylvania 16802 Received December 30, 1987; Revised Manuscript …
University Park, Pennsylvania 16802 Received December 30, 1987; Revised Manuscript …
Infidelity of DNA synthesis associated with bypass of apurinic sites.
RM Schaaper, TA Kunkel… - Proceedings of the …, 1983 - National Acad Sciences
The mutagenic potential of apurinic sites in vivo has been studied by transfection of
depurinated phi X174 DNA containing amber mutations into SOS-induced Escherichia coli …
depurinated phi X174 DNA containing amber mutations into SOS-induced Escherichia coli …
The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I.
K Bebenek, CM Joyce, MP Fitzgerald… - Journal of Biological …, 1990 - ASBMB
The fidelity of DNA synthesis by an exonuclease-proficient DNA polymerase results from the
selectivity of the polymerization reaction and from exonucleolytic proofreading. We have …
selectivity of the polymerization reaction and from exonucleolytic proofreading. We have …