The bone represents surprisingly dynamic structures that are subject to constant remodeling
by the concerted action of bone-forming osteoblasts and bone-resorbing osteoclasts-two cell …

With the application of modern investigative technologies, cholestatic liver diseases of
genetic etiology are increasingly identified as the root cause of previously designated …

Osteoclasts are multinucleated giant cells with the ability to degrade bone tissue, and are
closely related to abnormal bone metabolic diseases. Endoplasmic reticulum (ER) is an …

Osteoporosis (OP) is the most common orthopedic disease in the elderly and the main
cause of age‐related mortality and disability. However, no satisfactory intervention is …

The imbalance of bone homeostasis is the root cause of osteoporosis. However current
therapeutic approaches mainly focus on either anabolic or catabolic pathways, which often …

Background Tumour-derived extracellular vesicles (EVs) play a role in tumour progression;
however, the spectrum of molecular mechanisms regulating EV secretion and cargo …

Actin plays a critical role during the early stages of pathogenic microbe internalization by
immune cells. In this study, we identified a key mechanism of actin filament tethering and …

To meet the growing need for bone replacement of our aging population, development of
new adaptive biomaterials is essential. Collagen and glycosaminoglycans (GAGs) such as …

Actin is a central mediator between mechanical force and cellular phenotype. In tendons, it
is speculated that mechanical stress deprivation regulates gene expression by reducing …

Conclusions 64 Cu PET imaging enables visualization and quantification of the hepatic
copper retention characteristic for WD patients. This method represents a valuable tool for …