BACKGROUND Metabolic reprogramming is a hallmark of malignancy first recognized a
century ago. In some cases, reprogrammed metabolic activities can be exploited to …

Metabolic anomalies contribute to tissue dysfunction. Current metabolism research spans
from organelles to populations, and new technologies can accommodate investigation …

Metabolic reprogramming is central to malignant transformation and cancer cell growth. How
tumours use nutrients and the relative rates of reprogrammed pathways are areas of intense …

A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic
constraints imposed by the serine and glycine–limited brain environment restrict metastatic …

Prostate cancer (PCa) is one of the most prevalent malignancies in adult males. However,
PCa is resistant to multi-kinase inhibitors-based anti-angiogenic therapies, and the …

Radiation therapy (RT) continues to be one of the mainstays of cancer treatment.
Considerable efforts have been recently devoted to integrating MRI into clinical RT planning …

Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer, cancer-
associated fibroblasts (CAF) are major contributors of secreted lactate, which can be taken …

The tumour microenvironment is of critical importance in cancer development and
progression and includes the surrounding stromal and immune cells, extracellular matrix …

Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer
patients using 13C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized …

Hyperpolarised magnetic resonance imaging (HP 13C-MRI) is an emerging clinical
technique to detect [1-13C] lactate production in prostate cancer (PCa) following intravenous …