The aortic valve (AV) experiences a complex mechanical environment, which includes
tension, flexure, pressure, and shear stress forces due to blood flow during each cardiac …

Calcific aortic valve disease (CAVD) is a common acquired valvulopathy, which carries a
high burden of mortality. Chronic inflammation has been postulated as the predominant …

Calcification occurs in atherosclerotic vascular lesions and in the aortic valve. Calcific aortic
valve disease (CAVD) is a slow, progressive disorder that ranges from mild valve thickening …

The bicuspid aortic valve (BAV) is associated with a high prevalence of calcific aortic valve
disease (CAVD). Although abnormal hemodynamics has been proposed as a potential …

One of the most common acute and chronic cardiovascular disease conditions is aortic
stenosis, a disease in which the aortic valve is damaged and can no longer function …

The bicuspid aortic valve (BAV) is the most common congenital cardiac anomaly and is
frequently associated with calcific aortic valve disease (CAVD). The most prevalent type-I …

Calcific aortic valve disease (CAVD) is an active process presumably triggered by interplays
between cardiovascular risk factors, molecular signaling networks and hemodynamic cues …

Background Extracellular matrix (ECM) disarray is found in calcific aortic valvular disease
(CAVD), yet much remains to be learned about the role of individual ECM components in …

Aortic valve diseases are among the most common cardiovascular defects. Since a non-
functioning valve results in disturbed blood flow conditions, the diagnosis of such defects is …

Cardiovascular calcification can occur in vascular and valvular structures and is commonly
associated with calcium deposition and tissue mineralization leading to stiffness and …