Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Messenger RNA (mRNA)‐based therapeutic strategies have shown remarkable promise in
preventing and treating a staggering range of diseases. Optimizing the structure and …

Enzymes involved in RNA capping of SARS-CoV-2 are essential for the stability of viral
RNA, translation of mRNAs, and virus evasion from innate immunity, making them attractive …

Abstract Coronaviral methyltransferases (MTases), nsp10/16 and nsp14, catalyze the last
two steps of viral RNA-cap creation that takes place in cytoplasm. This cap is essential for …

Proteases encoded by SARS-CoV-2 constitute a promising target for new therapies against
COVID-19. SARS-CoV-2 main protease (Mpro, 3CLpro) and papain-like protease (PLpro) …

Taking advantage of the uniquely constricted active site of SARS-CoV-2 Nsp14
methyltransferase, we have designed bisubstrate inhibitors interacting with the SAM and …

The recent FDA approval of the mRNA vaccine for severe acute respiratory syndrome
coronavirus (SARS‐CoV‐2) emphasizes the importance of mRNA as a powerful tool for …

RNA methyltransferases (MTases) are ubiquitous enzymes whose hitherto low profile in
medicinal chemistry, contrasts with the surging interest in RNA methylation, the arguably …

Pollution and the rising energy demand have prompted the design of new synthetic
reactions that meet the principles of green chemistry. In particular, alternative synthesis of 2 …

Viral infections pose a persistent threat to human health. The relentless epidemic of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global health …