Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

[HTML][HTML] Involvement of astrocytes in Alzheimer's disease from a neuroinflammatory and oxidative stress perspective

RE González-Reyes, MO Nava-Mesa… - Frontiers in molecular …, 2017 - frontiersin.org
Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in
humans, but still no curative treatment has been developed. Although many explicative …

Astrocyte calcium signaling: the third wave

N Bazargani, D Attwell - Nature neuroscience, 2016 - nature.com
The discovery that transient elevations of calcium concentration occur in astrocytes, and
release'gliotransmitters' which act on neurons and vascular smooth muscle, led to the idea …

Astrocytes in physiological aging and Alzheimer's disease

JJ Rodríguez-Arellano, V Parpura, R Zorec… - Neuroscience, 2016 - Elsevier
Astrocytes are fundamental for homoeostasis, defence and regeneration of the central
nervous system. Loss of astroglial function and astroglial reactivity contributes to the aging of …

[HTML][HTML] Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis

QP Verhoog, L Holtman, E Aronica… - Frontiers in …, 2020 - frontiersin.org
Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …

Glial cells in Alzheimer's disease: From neuropathological changes to therapeutic implications

MS Uddin, LW Lim - Ageing research reviews, 2022 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that usually develops slowly and
progressively worsens over time. Although there has been increasing research interest in …

[HTML][HTML] Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments

M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …

Glial cells in (patho) physiology

V Parpura, MT Heneka, V Montana… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 121, 4–27. Abstract Neuroglial cells define brain homeostasis and
mount defense against pathological insults. Astroglia regulate neurogenesis and …

[HTML][HTML] Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle

SM Theparambil, PS Hosford, I Ruminot… - Nature …, 2020 - nature.com
Brain cells continuously produce and release protons into the extracellular space, with the
rate of acid production corresponding to the levels of neuronal activity and metabolism …

Local Ca2+ detection and modulation of synaptic release by astrocytes

MA Di Castro, J Chuquet, N Liaudet… - Nature …, 2011 - nature.com
Astrocytes communicate with synapses by means of intracellular calcium ([Ca2+] i)
elevations, but local calcium dynamics in astrocytic processes have never been thoroughly …