Osteoporosis is a bone disorder with remarkable changes in bone biologic material and
consequent bone structural distraction, affecting millions of people around the world from …

The use of genetically manipulated mouse models, gene and protein discovery and the
cataloguing of genetic mutations have each allowed us to obtain new insights into skeletal …

The recent identification of a link between bone mass in humans and gain-or loss-of-function
mutations in the Wnt coreceptor low-density lipoprotein receptor-related protein 5 …

Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass and increased risk of fragility fractures. Twin and family studies have …

Icariin is commonly used for the clinical treatment of osteonecrosis of the femoral head
(ONFH). miR-23a-3p plays a vital role in regulating the osteogenic differentiation of bone …

The identification of a link between bone mass in humans and gain‐[high bone mass (HBM)
trait] or loss‐of‐function [osteoporosis pseudoglioma (OPPG) syndrome] mutations in the …

The Runx2 gene is a master transcription factor of bone and plays a role in all stages of
bone formation. It is essential for the initial commitment of mesenchymal cells to the …

Sclerostin, encoded by the SOST gene, works as an inhibitor of the Wnt pathway and
therefore is an important regulator of bone homeostasis. Due to its potent action as an …

Osteoporosis is characterized by low bone mineral density and structural deterioration of
bone tissue, leading to an increased risk of fractures. It is the most common metabolic bone …

Osteoporotic fractures show reduced callus formation and delayed bone healing. Cellular
sources of fracture healing are mesenchymal stem cells (MSC) that differentiate into …