Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Catalysis has a central role in organic synthetic methodology, especially in stereoselective
reactions. In many reactions, enantioselectivity is made possible through the use of chiral …

Bolstered by recent advances in bioinformatics, genetics, and enzyme engineering, the field
of chemoenzymatic synthesis has enjoyed a rapid increase in popularity and utility. This …

Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …

Dehydronandrolone acetate (3) is a crucial precursor for the synthesis of C7-functionalized
steroidal drugs. However, the current production method involves a laborious and …

Natural products, a chemically and structurally diverse class of molecules, possess a wide
spectrum of biological activities, have been used therapeutically for millennia, and have …

The synthesis of steroid drugs by multistage modifications of the steroidal core is
challenging since site-specific and selective modification is essentially required, which is …

Many steroids are important pharmaceutically active compounds, while cytochrome P450
monooxygenases (CYPs) are attractive enzymes for applications in steroidal drug synthesis …

C14-functionalized steroids display biological activity and have been used as medicines.
The lack of synthetic methods to access C14-functionalized steroids has, however, impeded …

The selective oxygenation of nonactivated carbon atoms is an ongoing synthetic challenge,
and biocatalysts, particularly hemoprotein oxygenases, continue to be investigated for their …