Perivascular spaces in the brain: anatomy, physiology and pathology

JM Wardlaw, H Benveniste, M Nedergaard… - Nature Reviews …, 2020 - nature.com
Perivascular spaces include a variety of passageways around arterioles, capillaries and
venules in the brain, along which a range of substances can move. Although perivascular …

Understanding the role of the perivascular space in cerebral small vessel disease

R Brown, H Benveniste, SE Black… - Cardiovascular …, 2018 - academic.oup.com
Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

[HTML][HTML] Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology

K Gouveia-Freitas, AJ Bastos-Leite - Neuroradiology, 2021 - Springer
Perivascular spaces (PVS) of the brain, often called Virchow-Robin spaces, comprise fluid,
cells and connective tissue, and are externally limited by astrocytic endfeet. PVS are …

Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: a systematic review and meta-analysis

F Francis, L Ballerini… - International Journal of …, 2019 - journals.sagepub.com
Background Perivascular spaces, visible on brain magnetic resonance imaging, are thought
to be associated with small vessel disease, neuroinflammation, and to be important for …

[HTML][HTML] Imaging perivascular space structure and function using brain MRI

G Barisano, KM Lynch, F Sibilia, H Lan, NC Shih… - Neuroimage, 2022 - Elsevier
In this article, we provide an overview of current neuroimaging methods for studying
perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing …

[HTML][HTML] Perivascular unit: This must be the place. The anatomical crossroad between the immune, vascular and nervous system

F Troili, V Cipollini, M Moci, E Morena… - Frontiers in …, 2020 - frontiersin.org
Most neurological disorders seemingly have heterogenous pathogenesis, with overlapping
contribution of neuronal, immune and vascular mechanisms of brain injury. The perivascular …

Physiology and clinical relevance of enlarged perivascular spaces in the aging brain

CW Bown, RO Carare, MS Schrag, AL Jefferson - Neurology, 2022 - AAN Enterprises
Perivascular spaces (PVS) are fluid-filled compartments that are part of the cerebral blood
vessel wall and represent the conduit for fluid transport in and out of the brain. PVS are …

Body mass index, time of day and genetics affect perivascular spaces in the white matter

G Barisano, N Sheikh-Bahaei, M Law… - Journal of Cerebral …, 2021 - journals.sagepub.com
The analysis of cerebral perivascular spaces (PVS) using magnetic resonance imaging
(MRI) allows to explore in vivo their contributions to neurological disorders. To date the …

Association of MRI indices of glymphatic system with amyloid deposition and cognition in mild cognitive impairment and Alzheimer disease

K Kamagata, C Andica, K Takabayashi, Y Saito… - Neurology, 2022 - AAN Enterprises
Background and Objectives The glymphatic system is a whole-brain perivascular network,
which promotes CSF/interstitial fluid exchange. Alterations to this system may play a pivotal …

[HTML][HTML] Image processing approaches to enhance perivascular space visibility and quantification using MRI

F Sepehrband, G Barisano, N Sheikh-Bahaei… - Scientific reports, 2019 - nature.com
Imaging the perivascular spaces (PVS), also known as Virchow-Robin space, has significant
clinical value, but there remains a need for neuroimaging techniques to improve mapping …