[HTML][HTML] Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance
Y Wang, Y Chen, J Zhang, Y Yang, JS Fleishman… - Drug Resistance …, 2024 - Elsevier
Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of
copper and copper triggered cell death in the pathogenesis of cancers have attracted …
copper and copper triggered cell death in the pathogenesis of cancers have attracted …
Role of copper on mitochondrial function and metabolism
Copper is essential for life processes like energy metabolism, reactive oxygen species
detoxification, iron uptake, and signaling in eukaryotic organisms. Mitochondria gather …
detoxification, iron uptake, and signaling in eukaryotic organisms. Mitochondria gather …
Cuproptosis: Harnessing transition metal for cancer therapy
Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …
[HTML][HTML] Copper metabolism as a unique vulnerability in cancer
The last 25 years have witnessed tremendous progress in identifying and characterizing
proteins that regulate the uptake, intracellular trafficking and export of copper. Although …
proteins that regulate the uptake, intracellular trafficking and export of copper. Although …
The multifaceted roles of copper in cancer: A trace metal element with dysregulated metabolism, but also a target or a bullet for therapy
Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …
can be detrimental for the cell that developed highly coordinated pathways to chelate and …
[HTML][HTML] Copper in cancer: from pathogenesis to therapy
D Guan, L Zhao, X Shi, X Ma, Z Chen - Biomedicine & Pharmacotherapy, 2023 - Elsevier
One of the basic trace elements for the structure and metabolism of human tissue is copper.
However, as a heavy metal, excessive intake or abnormal accumulation of copper in the …
However, as a heavy metal, excessive intake or abnormal accumulation of copper in the …
Mitochondrial copper in human genetic disorders
Copper is an essential micronutrient that serves as a cofactor for enzymes involved in
diverse physiological processes, including mitochondrial energy generation. Copper enters …
diverse physiological processes, including mitochondrial energy generation. Copper enters …
[HTML][HTML] Getting out what you put in: Copper in mitochondria and its impacts on human disease
Mitochondria accumulate copper in their matrix for the eventual maturation of the
cuproenzymes cytochrome c oxidase and superoxide dismutase. Transport into the matrix is …
cuproenzymes cytochrome c oxidase and superoxide dismutase. Transport into the matrix is …
Micropeptide ASAP encoded by LINC00467 promotes colorectal cancer progression by directly modulating ATP synthase activity
Emerging evidence has shown that open reading frames inside long noncoding RNAs
(lncRNAs) could encode micropeptides. However, their roles in cellular energy metabolism …
(lncRNAs) could encode micropeptides. However, their roles in cellular energy metabolism …
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
About a thousand genes in the human genome encode for membrane transporters. Among
these, several solute carrier proteins (SLCs), representing the largest group of transporters …
these, several solute carrier proteins (SLCs), representing the largest group of transporters …