A structural perspective on the regulation of the epidermal growth factor receptor
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that plays a
critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor …
critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor …
The epidermal growth factor receptor ligands at a glance
MR Schneider, E Wolf - Journal of cellular physiology, 2009 - Wiley Online Library
The epidermal growth factor receptor (EGFR) regulates key processes of cell biology,
including proliferation, survival, and differentiation during development, tissue homeostasis …
including proliferation, survival, and differentiation during development, tissue homeostasis …
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
The kinase domain of human epidermal growth factor receptor (HER) 3/ErbB3, a member of
the EGF receptor (EGFR) family, lacks several residues that are critical for catalysis …
the EGF receptor (EGFR) family, lacks several residues that are critical for catalysis …
The ERBB3 receptor in cancer and cancer gene therapy
G Sithanandam, LM Anderson - Cancer gene therapy, 2008 - nature.com
ERBB3, a member of the epidermal growth factor receptor (EGFR) family, is unique in that its
tyrosine kinase domain is functionally defective. It is activated by neuregulins, by other …
tyrosine kinase domain is functionally defective. It is activated by neuregulins, by other …
Evolution of the insulin-like growth factor binding protein (IGFBP) family
The evolution of the IGF binding protein (IGFBP) gene family has been difficult to resolve.
Both chromosomal and serial duplications have been suggested as mechanisms for the …
Both chromosomal and serial duplications have been suggested as mechanisms for the …
The maintenance and regeneration of the planarian excretory system are regulated by EGFR signaling
The maintenance of organs and their regeneration in case of injury are crucial to the survival
of all animals. High rates of tissue turnover and nearly unlimited regenerative capabilities …
of all animals. High rates of tissue turnover and nearly unlimited regenerative capabilities …
Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation
EH Budi, LB Patterson, DM Parichy - 2008 - journals.biologists.com
Vertebrate pigment cells are derived from neural crest cells and are a useful system for
studying neural crest-derived traits during post-embryonic development. In zebrafish, neural …
studying neural crest-derived traits during post-embryonic development. In zebrafish, neural …
[HTML][HTML] QSAR based model for discriminating EGFR inhibitors and non-inhibitors using Random forest
Abstract Background Epidermal Growth Factor Receptor (EGFR) is a well-characterized
cancer drug target. In the past, several QSAR models have been developed for predicting …
cancer drug target. In the past, several QSAR models have been developed for predicting …
[HTML][HTML] Mechanisms of receptor tyrosine-protein kinase ErbB-3 (ERBB3) action in human neoplasia
LE Black, JF Longo, SL Carroll - The American Journal of Pathology, 2019 - Elsevier
It is well established that the epidermal growth factor (EGF) receptor, receptor tyrosine-
protein kinase erbB-2 (ERBB2)/human EGF receptor 2 (HER2), and, to a lesser extent …
protein kinase erbB-2 (ERBB2)/human EGF receptor 2 (HER2), and, to a lesser extent …
The chromosome-scale genome assembly of the yellowtail clownfish Amphiprion clarkii provides insights into the melanic pigmentation of anemonefish
Anemonefish are an emerging group of model organisms for studying genetic, ecological,
evolutionary, and developmental traits of coral reef fish. The yellowtail clownfish Amphiprion …
evolutionary, and developmental traits of coral reef fish. The yellowtail clownfish Amphiprion …