Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

Inhibition of carbonic anhydrase (CA, EC 4.2. 1.1) was clinically exploited for decades, as
most modern diuretics were obtained considering as lead molecule acetazolamide, the …

Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …

Introduction Four different genetic families of the enzyme carbonic anhydrase (CA, EC 4.2.
1.1) are present in bacteria, α-, β-, γ-and ι-CAs. They play relevant functions related to CO2 …

Bacteria encode carbonic anhydrases (CAs, EC 4.2. 1.1) belonging to three different genetic
families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these …

Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) have been studied for decades and have
been classified as a superfamily of enzymes which includes, up to date, eight gene families …

Introduction The clinically licensed drugs used as antibiotics prevent the microbial growth
interfering with the biosynthesis of proteins, nucleic acids, microorganism wall biosynthesis …

Introduction The spacious active site cavity of the metalloenzyme carbonic anhydrase (CA,
EC 4.2. 1.1) shows a great versatility for a variety of binding modes for modulators of activity …

The carbonic anhydrases (CAs, EC 4.2. 1.1) catalyse a simple but physiologically crucial
reversible reaction, the carbon dioxide hydration with the production of bicarbonate and …

Resistance to antibiotic treatment developed by bacteria in humans and animals occurs
when the microorganisms resist treatment with clinically approved antibiotics. Actions must …