Idiosyncratic drug-induced liver injury (DILI) is a common cause for drug withdrawal from the
market and although infrequent, DILI can result in serious clinical outcomes including acute …

Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly
contribute to vascular and cardiac physiology. The contribution of EETs to vascular and …

Periparturient dairy cows experience an increased incidence and severity of several
inflammatory-based diseases such as mastitis and metritis. Factors associated with the …

Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …

Immune system activation through innate and adaptive systemic mechanisms is critical for
protection from pathogens and other antigens. However, uncontrolled systemic inflammation …

Cytochrome P450-dependent ω-hydroxylation is a prototypic metabolic reaction of CYP4
family members that is important for the elimination and bioactivation of not only therapeutic …

The mechanisms underlying the anti-inflammatory and antihypertensive effects of long-chain
ω-3 polyunsaturated fatty acids (ω-3 PUFAs) are still unclear. The epoxides of an ω-6 fatty …

Kaempferol has been confirmed to be effective in improving metabolic diseases such as
diabetes and obesity. However, its effect and mechanism in nonalcoholic steatohepatitis …

Liver cancer is a malignancy developed from underlying liver disease that encompasses
liver injury and metabolic disorders. The progression from these underlying liver disease to …

The xenobiotic metabolism in the lung, an organ of first entry of xenobiotics into the
organism, is crucial for inhaled compounds entering this organ intentionally (eg drugs) and …