Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to
adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence …

Abstract Fragala, MS, Cadore, EL, Dorgo, S, Izquierdo, M, Kraemer, WJ, Peterson, MD, and
Ryan, ED. Resistance training for older adults: position statement from the national strength …

This review proposes that physical inactivity could be considered a behavior selected by
evolution for resting, and also selected to be reinforcing in life-threatening situations in …

One of the leading causes of morbidity and premature mortality in older people is frailty.
Frailty occurs when multiple physiological systems decline, to the extent that an individual's …

Objective To systematically review the research conducted on prevalence of frailty and
prefrailty among community-dwelling older adults in low-income and middle-income …

Over the past 100 years, advances in medicine and public health have led to a nearly 2-fold
increase in average lifespan. 1 Approximately 8.5% of the global population is 65 years or …

Frailty, a syndrome characterized by an exaggerated decline in function and reserve of
multiple physiological systems, is common in older patients with heart failure (HF) and is …

The medical syndrome of frailty is widely recognized, yet debate remains over how best to
measure it in clinical and research settings. This study reviewed the frailty-related research …

Background. Frailty assessment provides a means of identifying older adults most
vulnerable to adverse outcomes. Attention to frailty in clinical practice is more likely with …