[HTML][HTML] Integrated modeling of biomarkers, survival and safety in clinical oncology drug development
H Liu, EIK Ibrahim, M Centanni, C Sarr… - Advanced Drug Delivery …, 2024 - Elsevier
Abstract Model-based approaches, including population pharmacokinetic-
pharmacodynamic modeling, have become an essential component in the clinical phases of …
pharmacodynamic modeling, have become an essential component in the clinical phases of …
Application of Pharmacometrics of 5-Fluorouracil to Personalized Medicine: A Tool for Predicting Pharmacokinetic–Pharmacodynamic/Toxicodynamic Responses
S Kobuchi, Y Ito - Anticancer Research, 2020 - ar.iiarjournals.org
Recently, therapeutic drug monitoring of 5-fluorouracil (5-FU), the key chemotherapeutic
drug for colorectal cancer, has been applied in daily clinical practice and has contributed …
drug for colorectal cancer, has been applied in daily clinical practice and has contributed …
Patient-related characteristics associated with treatment modifications and suboptimal relative dose intensity of neoadjuvant chemotherapy in patients with breast …
E Kjeldsted, J Gehl, DM Sørensen, A Lodin… - Cancers, 2023 - mdpi.com
Simple Summary This study aimed to examine clinical practice patterns of adherence to the
planned neoadjuvant chemotherapy doses, patient-related characteristics associated with …
planned neoadjuvant chemotherapy doses, patient-related characteristics associated with …
Pharmacogenetics in Oncology: A useful tool for individualizing drug therapy
R Nogueiras‐Álvarez… - British Journal of Clinical …, 2024 - Wiley Online Library
With the continuous development of genetics in healthcare, there has been a significant
contribution to the development of precision medicine, which is ultimately aimed at …
contribution to the development of precision medicine, which is ultimately aimed at …
Therapeutic drug monitoring of amikacin in neutropenic oncology patients
M Aquino, M Tinoco, J Bicker, A Falcão, M Rocha… - Antibiotics, 2023 - mdpi.com
Amikacin is the antibiotic of choice for the treatment of Gram-negative infections, namely,
those in neutropenic oncology patients. No populational pharmacokinetic studies are …
those in neutropenic oncology patients. No populational pharmacokinetic studies are …
[HTML][HTML] Optimizing cancer therapy for individuals based on tumor-immune-drug system interaction
X Chen, T Li, W Cao - Mathematical Biosciences and Engineering, 2023 - aimspress.com
Chemotherapy is a crucial component of cancer therapy, albeit with significant side effects.
Chemotherapy either damages or inhibits the immune system; therefore, its efficacy varies …
Chemotherapy either damages or inhibits the immune system; therefore, its efficacy varies …
Association of volatile anesthesia exposure and depth with emergence agitation and delirium in children: Prospective observational cohort study
Y Zhang, Q Zhang, S Xu, X Zhang, W Gao… - Frontiers in …, 2023 - frontiersin.org
Background Sevoflurane anesthesia is widely used in pediatric ambulatory surgery.
However, emergency agitation (EA) and emergency delirium (ED), as major complications …
However, emergency agitation (EA) and emergency delirium (ED), as major complications …
Conception et validation de modèles optimaux pour le ciblage thérapeutique en oncologie par des méthodes issues de l'intelligence artificielle
V Leclerc - 2022 - theses.hal.science
La prise en charge des cancers est aujourd'hui une priorité de santé publique. Pour cela se
développent de plus en plus de nouveaux traitements dits de précision, et ce que l'on …
développent de plus en plus de nouveaux traitements dits de précision, et ce que l'on …