Metabolic syndrome is an inflammatory disorder: A conspiracy between adipose tissue and phagocytes

P Reddy, D Lent-Schochet, N Ramakrishnan… - Clinica Chimica …, 2019 - Elsevier
Metabolic syndrome (MetS) describes a cluster of cardio-metabolic factors that predispose to
type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD). While …

[HTML][HTML] Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and …

UJ Jung, MS Choi - International journal of molecular sciences, 2014 - mdpi.com
Accumulating evidence indicates that obesity is closely associated with an increased risk of
metabolic diseases such as insulin resistance, type 2 diabetes, dyslipidemia and …

Adipokines in inflammation and metabolic disease

N Ouchi, JL Parker, JJ Lugus, K Walsh - Nature reviews immunology, 2011 - nature.com
The worldwide epidemic of obesity has brought considerable attention to research aimed at
understanding the biology of adipocytes (fat cells) and the events occurring in adipose …

[HTML][HTML] Adipokines and insulin resistance

K Rabe, M Lehrke, KG Parhofer, UC Broedl - Molecular medicine, 2008 - Springer
Obesity is associated with an array of health problems in adult and pediatric populations.
Understanding the pathogenesis of obesity and its metabolic sequelae has advanced …

Visfatin Induces Inflammation and Insulin Resistance via the NF‐κB and STAT3 Signaling Pathways in Hepatocytes

YJ Heo, SE Choi, JY Jeon, SJ Han… - Journal of diabetes …, 2019 - Wiley Online Library
Background. It has been suggested that visfatin, which is an adipocytokine, exhibits
proinflammatory properties and is associated with insulin resistance. Insulin resistance and …

Mechanism of endothelial dysfunction in chronic kidney disease

J Malyszko - Clinica chimica acta, 2010 - Elsevier
Endothelium is the largest organ in the body strategically located between the wall of blood
vessels and the blood stream. The human body contains approximately 1013 endothelial …

Visfatin/Nampt: an adipokine with cardiovascular impact

T Romacho, CF Sánchez-Ferrer… - Mediators of …, 2013 - Wiley Online Library
Adipose tissue is acknowledged as an endocrine organ that releases bioactive factors
termed adipokines. Visfatin was initially identified as a novel adipokine with insulin‐mimetic …

[HTML][HTML] Role of visfatin in obesity-induced insulin resistance

MMI Abdalla - World journal of clinical cases, 2022 - ncbi.nlm.nih.gov
The growing worldwide burden of insulin resistance (IR) emphasizes the importance of early
identification for improved management. Obesity, particularly visceral obesity, has been a …

[PDF][PDF] State of the art paper Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns

GS Papaetis, P Papakyriakou… - Archives of Medical …, 2015 - termedia.pl
The prevalence of type 2 diabetes (T2D) is rapidly increasing. This is strongly related to the
contemporary lifestyle changes that have resulted in increased rates of overweight …

Association of plasma visfatin levels with inflammation, atherosclerosis and acute coronary syndromes (ACS) in humans

SW Liu, SB Qiao, JS Yuan, DQ Liu - Clinical endocrinology, 2009 - Wiley Online Library
Objectives Visfatin is a new cytokine that act as an insulin analogue on the insulin receptor
and may link obesity and insulin resistance. It was recently shown that visfatin plays a role in …