Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …

Autophagosome biogenesis is a dynamic membrane event, which is executed by the
sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup …

Healthy cells use autophagy as a general'housekeeping'mechanism and to survive stress,
including stress induced by nutrient deprivation. Autophagy is initiated at the isolation …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Background Autophagy is an intracellular degradation system that removes unnecessary or
dysfunctional components and recycles them for other cellular functions. Over the years, a …

Mammalian cells remove misfolded proteins using various proteolytic systems, including the
ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and …

It is not clear to what extent starvation-induced autophagy affects the proteome on a global
scale and whether it is selective. In this study, we report based on quantitative proteomics …

Lipid-mediated signalling regulates a plethora of physiological processes, including crucial
aspects of brain function. In addition, dysregulation of lipid pathways has been implicated in …

Lipids are key regulators of brain function and have been increasingly implicated in
neurodegenerative disorders including Alzheimer disease (AD). Here, a systems-based …

Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of
cells and organisms. Cells rely on a sophisticated but poorly understood network of …