Abstract γδ T cells form an important part of adaptive immune responses against infections
and malignant transformation. The molecular targets of human γδ T cell receptors (TCRs) …

CD8+ cytotoxic T lymphocytes (CTLs) play a crucial role in targeting virus-infected and
cancer cells. Although other cytotoxic lymphocytes such as CD4+ T and natural killer (NK) …

Adoptive T‐cell transfer (ACT) therapies, including of tumor infiltrating lymphocytes (TILs)
and T cells gene‐modified to express either a T cell receptor (TCR) or a chimeric antigen …

Over the last several years, there has been considerable progress in the treatment of cancer
using gene modified adoptive T cell therapies. Two approaches have been used, one …

Leukemia relapse remains the major cause of allogeneic hematopoietic stem cell
transplantation (HCT) failure, and the prognosis for patients with post-HCT relapse is poor …

Peptide–MHC (pMHC) multimers have become the “gold standard” for the detection and
isolation of antigen-specific T-cells but recent evidence shows that normal use of these …

Cytotoxic T cells recognize, via their T cell receptors (TCRs), small antigenic peptides
presented by the major histocompatibility complex (pMHC) on the surface of professional …

Fluorochrome-conjugated peptide–major histocompatibility complex (pMHC) multimers are
widely used for flow cytometric visualization of antigen-specific T cells. The most common …

Abstract Chimeric Antigen Receptor T cell (CAR-T) therapy has emerged as a transformative
therapeutic strategy for hematological malignancies. However, its efficacy in treating solid …

Some G protein–coupled receptors (GPCRs) demonstrate biased signaling such that
ligands of the same receptor exclusively or preferentially activate certain downstream …