Background: Cardiomyopathies are a heterogeneous group of pathologies characterized by
structural and functional alterations of the heart. Aims: The purpose of this narrative review is …

With the advent of technologies to obtain the complete sequence of the human genome in a
cost-effective manner, this decade and those to come will see an exponential increase in our …

Sudden cardiac death (SCD) in an athlete is a rare yet highly visible tragedy that generates
significant media attention and discussion among medical personnel, sports communities …

Background—Current information on the epidemiology and outcomes of hypertrophic
cardiomyopathy (HCM) in children is limited by disease diversity and small case series …

During the past 5 years there has been an increasing body of literature describing the roles
cardiac myosin binding protein C (cMyBP-C) phosphorylation play in regulating cardiac …

Background—The ubiquitin proteasome system maintains a dynamic equilibrium of proteins
and prevents accumulation of damaged and misfolded proteins, yet its role in human cardiac …

Heart failure is a leading cause of mortality in South Asians. However, its genetic etiology
remains largely unknown. Cardiomyopathies due to sarcomeric mutations are a major …

The molecular millennium has bestowed researchers with the essential tools to identify the
underlying genetic substrates for thousands of genetic disorders, most of which are rare and …

Objectives To determine the prevalence and spectrum of mutations and genotype-
phenotype relationships in the largest hypertrophic cardiomyopathy (HCM) cohort to date …

OBJECTIVE To examine the relationship among age, septal morphological subtype, and
presence of hypertrophic cardiomyopathy (HCM)-associated myofilament mutations …