Zebrafish as an animal model for biomedical research

TY Choi, TI Choi, YR Lee, SK Choe… - Experimental & Molecular …, 2021 - nature.com
Zebrafish have several advantages compared to other vertebrate models used in modeling
human diseases, particularly for large-scale genetic mutant and therapeutic compound …

Little fish, big data: zebrafish as a model for cardiovascular and metabolic disease

P Gut, S Reischauer, DYR Stainier… - Physiological …, 2017 - journals.physiology.org
The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

[HTML][HTML] A new perspective on lipid research in age-related macular degeneration

EM van Leeuwen, E Emri, BMJ Merle, JM Colijn… - Progress in retinal and …, 2018 - Elsevier
There is an urgency to find new treatment strategies that could prevent or delay the onset or
progression of AMD. Different classes of lipids and lipoproteins metabolism genes have …

Zebrafish embryonic lipidomic analysis reveals that the yolk cell is metabolically active in processing lipid

D Fraher, A Sanigorski, NA Mellett, PJ Meikle… - Cell reports, 2016 - cell.com
The role of lipids in providing energy and structural cellular components during vertebrate
development is poorly understood. To elucidate these roles further, we visualized lipid …

Epigenetics in teleost fish: From molecular mechanisms to physiological phenotypes

C Best, H Ikert, DJ Kostyniuk, PM Craig… - … and Physiology Part B …, 2018 - Elsevier
While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …

The zebrafish as a model for gastrointestinal tract–microbe interactions

EM Flores, AT Nguyen, MA Odem… - Cellular …, 2020 - Wiley Online Library
The zebrafish (Danio rerio) has become a widely used vertebrate model for bacterial, fungal,
viral, and protozoan infections. Due to its genetic tractability, large clutch sizes, ease of …

Inside the β cell: molecular stress response pathways in diabetes pathogenesis

A Kulkarni, C Muralidharan, SC May, SA Tersey… - …, 2023 - academic.oup.com
The pathogeneses of the 2 major forms of diabetes, type 1 and type 2, differ with respect to
their major molecular insults (loss of immune tolerance and onset of tissue insulin …

Zebrafish: An emerging model system to study liver diseases and related drug discovery

S Katoch, V Patial - Journal of applied toxicology, 2021 - Wiley Online Library
The zebrafish has emerged as a powerful vertebrate model for studying liver‐associated
disorders. Liver damage is a crucial problem in the process of drug development and …

Integrative physiology: at the crossroads of nutrition, microbiota, animal physiology, and human health

F Leulier, LT MacNeil, W Lee, JF Rawls, PD Cani… - Cell metabolism, 2017 - cell.com
Nutrition is paramount in shaping all aspects of animal biology. In addition, the influence of
the intestinal microbiota on physiology is now widely recognized. Given that diet also …

[PDF][PDF] Zebrafish as An Emerging Model: An Important Testing Platform for Biomedical Science

A Dubey - Journal of Pharmaceutical Negative Results, 2022 - pnrjournal.com
This is a good thing because animals show other organisms how to stay healthy in their
environment. Biologists can learn more about a lot ofdifferent biological processes by …