Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease
that can cause severe pain and dysfunction. It has a serious impact on the quality of lives of …

The temporomandibular joint (TMJ) is a small synovial joint at which the mandible articulates
with the skull during movements involved in speaking and mastication. However, the …

For decades, it has been widely accepted that hypertrophic chondrocytes undergo apoptosis
prior to endochondral bone formation. However, very recent studies in long bone suggest …

Despite years of research investigating osteoblast differentiation, the mechanisms by which
transcription factors regulate osteoblast maturation, bone formation, and bone homeostasis …

Osterix (Osx), a transcriptional factor essential for osteogenesis, is also critical for in vivo
cellular cementum formation. However, the molecular mechanism by which Osx regulates …

Background Our recent studies demonstrate that the focal adhesion protein Kindlin-2 exerts
crucial functions in the mesenchymal stem cells, mature osteoblasts and osteocytes in …

Tooth is made of crown and root. It is widely believed that dentin formation in crown and root
uses the same regulatory mechanism. However, identification of nuclear factor 1 C (NFIC)'s …

Objective Chondrogenesis and endochondral ossification in mandibular condyle play
crucial roles in maxillofacial morphogenesis and function. Circadian regulator brain and …

Cell condensation and mechanical stimuli play roles in osteogenesis and chondrogenesis;
thus, they are promising for facilitating self-organizing bone/cartilage tissue formation in vitro …

Abstract β-Catenin plays a critical role in cartilage formation and development. To further
understand the role of β-catenin in osteoarthritis (OA) development in temporomandibular …