Liver cancer is the third leading cause of cancer death worldwide. Representing such a
dramatic impact on our lives, liver cancer is a significant public health concern. Sustainable …

The canonical Wnt–β-catenin pathway is a complex, evolutionarily conserved signalling
mechanism that regulates fundamental physiological and pathological processes. Wnt–β …

Hepatocellular carcinoma is the third leading cause of deaths from cancer worldwide.
Infection with the hepatitis B virus is one of the leading risk factors for developing …

Purpose Following the Sorafenib Hepatocellular Carcinoma Assessment Randomized
Protocol (SHARP) trial, sorafenib has become the standard of care for patients with …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths
worldwide. Although recent advances in therapeutic approaches for treating HCC have …

Obesity has been recognized as a key component of the metabolic syndrome, a cluster of
risk factors associated with diabetes and cardiovascular morbidity. In addition, obesity has …

Viral oncogenesis is a multistep process largely depending on the complex interplay
between viruses and host factors. The oncoviruses are capable of subverting the cell …

Hepatocellular carcinoma (HCC) is the third most frequent cause of tumor-related mortality
and there are an estimated approximately 850,000 new cases annually. Most HCC patients …

Various cancer stem cell (CSC) biomarkers have been identified for hepatocellular
carcinoma (HCC), but little is known about the implications of heterogeneity and shared …

The canonical WNT pathway regulates the stability of the proto-oncogene β-catenin and is
aberrantly activated in many cancer types. Studies in a wide range of experimental models …