Genetic, environmental, and aging-related insults can promote the misfolding and
subsequent aggregation of secreted proteins implicated in the pathogenesis of numerous …

The extracellular protein, transthyretin is responsible for the transport of thyroxin and retinol
binding protein complex to the various parts of the body. In addition to this transport function …

Alzheimer's disease is associated with the deposition of the amyloid-β peptide (Aβ) into
extracellular senile plaques in the brain. In vitro and in vivo observations have indicated that …

Transthyretin (TTR), an homotetrameric protein mainly synthesized by the liver and the
choroid plexus, and secreted into the blood and the cerebrospinal fluid, respectively, has …

The aggregation of amyloidogenic proteins is a pathological hallmark of various
neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and …

Background Alzheimer's disease (AD) is a neurodegenerative disorder and is the most
common cause of late-onset dementia. Microglia, the primary innate immune cells of the …

Protein aggregation and subsequent accumulation of insoluble amyloid fibrils with cross-β
structure is an intrinsic characteristic of amyloid diseases, ie, amyloidoses. Amyloid …

Transthyretin (TTR) has a well-established role in neuroprotection in Alzheimer's Disease
(AD). We have setup a drug discovery program of small-molecule compounds that act as …

Amyloid formation is a pathological process associated with a wide range of degenerative
disorders, including Alzheimer's disease, Parkinson's disease, and diabetes mellitus type 2 …

Transthyretin (TTR) modulates the deposition, processing, and toxicity of Abeta (Aβ)
peptides. We have shown that this effect is enhanced in mice by treatment with small …