Eravacycline (Xerava™), a novel fully synthetic fluorocycline, consists of the tetracyclic core
scaffold with unique modifications in the tetracyclic D ring; consequently, it exhibits potent in …

Gram-negative bacterial resistance to antimicrobials has had an exponential increase at a
global level during the last decades and represent an everyday challenge, especially for the …

Complicated intra-abdominal infections (cIAIs) are commonly associated with
multimicroorganisms and treatment choices are becoming narrower due to developing …

Pharmacokinetics and pharmacodynamics are areas in pharmacology related to different
themes in the pharmaceutical sciences, including therapeutic drug monitoring and different …

Introduction: Infections caused by multidrug-resistant Gram-negative bacteria (MDR-GNB)
are associated with significant mortality and costs. New drugs in development to combat …

Ventilator-associated pneumonia (VAP) remains an important clinical problem globally,
being associated with significant morbidity and mortality. As management of VAP requires …

Acinetobacter baumannii remains a difficult-to-treat pathogen that poses a significant
challenge to clinicians and costs to the healthcare system. There is a lack of clinical efficacy …

Background Mortality rates for patients with Staphylococcus aureus (S. aureus) infections
have improved only modestly in recent decades and S. aureus infections remain a major …

Purpose To better guide clinical use, we determined the in vitro antimicrobial activity of the
new drug eravacycline and other tetracycline derivatives against levofloxacin (LVFX)-non …

Aims The aims of this study were to compare the antimicrobial efficacy of Eravacycline
(Erava) versus tigecycline (Tig) in vitro against clinical isolates of S. agalactiae from China …