Experimental investigation of herpes simplex virus latency
EK Wagner, DC Bloom - Clinical microbiology reviews, 1997 - Am Soc Microbiol
The clinical manifestations of herpes simplex virus infection generally involve a mild and
localized primary infection followed by asymptomatic (latent) infection interrupted …
localized primary infection followed by asymptomatic (latent) infection interrupted …
Alphaherpesvirus latency: its role in disease and survival of the virus in nature
C Jones - Advances in virus research, 1998 - Elsevier
Publisher Summary Herpesviruses have been identified that infect nearly all groups of
vertebrates. This chapter focuses on the latency of α-herpesviruses. Several mammalian …
vertebrates. This chapter focuses on the latency of α-herpesviruses. Several mammalian …
The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency
GC Perng, EC Dunkel, PA Geary, SM Slanina… - Journal of …, 1994 - Am Soc Microbiol
During herpes simplex virus type 1 (HSV-1) neuronal latency, the only viral RNA detected is
from the latency-associated transcript (LAT) gene. We have made a LAT deletion mutant of …
from the latency-associated transcript (LAT) gene. We have made a LAT deletion mutant of …
Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus
MF Kramer, DM Coen - Journal of virology, 1995 - Am Soc Microbiol
Herpes simplex virus establishes latency in nervous tissue in which it is maintained for the
life of the mammalian host, with occasional reactivation leading to subsequent spread …
life of the mammalian host, with occasional reactivation leading to subsequent spread …
A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1
DA Garber, PA Schaffer, DM Knipe - Journal of virology, 1997 - Am Soc Microbiol
Herpes simplex virus (HSV) persists in the human population by establishing long-term
latent infections followed by periodic reactivation and transmission. Latent infection of …
latent infections followed by periodic reactivation and transmission. Latent infection of …
A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus
SH Chen, MF Kramer, PA Schaffer, DM Coen - Journal of virology, 1997 - Am Soc Microbiol
Latent infections of neurons by herpes simplex virus form reservoirs of recurrent viral
infections that resist cure. In latently infected neurons, viral gene expression is severely …
infections that resist cure. In latently infected neurons, viral gene expression is severely …
Ocular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated?
LJ Al-Dujaili, PP Clerkin, C Clement… - Future …, 2011 - Taylor & Francis
Most humans are infected with herpes simplex virus (HSV) type 1 in early childhood and
remain latently infected throughout life. While most individuals have mild or no symptoms …
remain latently infected throughout life. While most individuals have mild or no symptoms …
Mechanisms of herpes simplex virus type 1 reactivation
WP Halford, BM Gebhardt, DJ Carr - Journal of virology, 1996 - Am Soc Microbiol
Primary cultures of trigeminal ganglion (TG) cells from herpes simplex virus type 1 (HSV-1)
latently infected mice were used to study reactivation. Expression of HSV-1 latency …
latently infected mice were used to study reactivation. Expression of HSV-1 latency …
The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary …
The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is
essential for efficient spontaneous reactivation of HSV-1 from latency. We report here that …
essential for efficient spontaneous reactivation of HSV-1 from latency. We report here that …
Ocular HSV-1 latency, reactivation and recurrent disease
HS Toma, AT Murina, RG Areaux Jr… - Seminars in …, 2008 - Taylor & Francis
Ocular infection with HSV-1 continues to be a serious clinical problem despite the
availability of effective antivirals. Primary infection with HSV-1 can involve ocular and …
availability of effective antivirals. Primary infection with HSV-1 can involve ocular and …