Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions

DR Nässel, M Zandawala - Open Biology, 2022 - royalsocietypublishing.org
Plasticity in animal behaviour relies on the ability to integrate external and internal cues from
the changing environment and hence modulate activity in synaptic circuits of the brain. This …

[HTML][HTML] Connectomics and the neural basis of behaviour

DS Galili, GSXE Jefferis, M Costa - Current opinion in insect science, 2022 - Elsevier
Highlights•Technical advances are producing bigger and denser Drosophila melanogaster
connectomes.•Mapping connectomics to other data types is a challenging but crucial …

[HTML][HTML] Molecular topography of an entire nervous system

SR Taylor, G Santpere, A Weinreb, A Barrett, MB Reilly… - Cell, 2021 - cell.com
We have produced gene expression profiles of all 302 neurons of the C. elegans nervous
system that match the single-cell resolution of its anatomy and wiring diagram. Our results …

Neuronal diversity and convergence in a visual system developmental atlas

MN Özel, F Simon, S Jafari, I Holguera, YC Chen… - Nature, 2021 - nature.com
Deciphering how neuronal diversity is established and maintained requires a detailed
knowledge of neuronal gene expression throughout development. In contrast to mammalian …

[HTML][HTML] Transcriptional programs of circuit assembly in the Drosophila visual system

YZ Kurmangaliyev, J Yoo, J Valdes-Aleman… - Neuron, 2020 - cell.com
Precise patterns of synaptic connections between neurons are encoded in their genetic
programs. Here, we use single-cell RNA sequencing to profile neuronal transcriptomes at …

Unique homeobox codes delineate all the neuron classes of C. elegans

MB Reilly, C Cros, E Varol, E Yemini, O Hobert - Nature, 2020 - nature.com
It is not known at present whether neuronal cell-type diversity—defined by cell-type-specific
anatomical, biophysical, functional and molecular signatures—can be reduced to relatively …

Decoding gene regulation in the fly brain

J Janssens, S Aibar, II Taskiran, JN Ismail, AE Gomez… - Nature, 2022 - nature.com
The Drosophila brain is a frequently used model in neuroscience. Single-cell transcriptome
analysis,,,,–, three-dimensional morphological classification and electron microscopy …

Synaptic architecture of leg and wing premotor control networks in Drosophila

E Lesser, AW Azevedo, JS Phelps, L Elabbady, A Cook… - Nature, 2024 - nature.com
Animal movement is controlled by motor neurons (MNs), which project out of the central
nervous system to activate muscles. MN activity is coordinated by complex premotor …

Global change in brain state during spontaneous and forced walk in Drosophila is composed of combined activity patterns of different neuron classes

S Aimon, KY Cheng, J Gjorgjieva, ICG Kadow - Elife, 2023 - elifesciences.org
Movement-correlated brain activity has been found across species and brain regions. Here,
we used fast whole brain lightfield imaging in adult Drosophila to investigate the relationship …

[HTML][HTML] Glial metabolic rewiring promotes axon regeneration and functional recovery in the central nervous system

F Li, A Sami, HN Noristani, K Slattery, J Qiu, T Groves… - Cell metabolism, 2020 - cell.com
Axons in the mature central nervous system (CNS) fail to regenerate after axotomy, partly
due to the inhibitory environment constituted by reactive glial cells producing astrocytic …