CD44 as a tumor biomarker and therapeutic target

H Xu, M Niu, X Yuan, K Wu, A Liu - Experimental hematology & oncology, 2020 - Springer
CD44, a complex transmembrane glycoprotein, exists in multiple molecular forms, including
the standard isoform CD44s and CD44 variant isoforms. CD44 participates in multiple …

Exploring cellular biochemistry with nanobodies

RW Cheloha, TJ Harmand, C Wijne… - Journal of Biological …, 2020 - ASBMB
Reagents that bind tightly and specifically to biomolecules of interest remain essential in the
exploration of biology and in their ultimate application to medicine. Besides ligands for …

Single Domain Antibodies Targeting Receptor Binding Pockets of NadA Restrain Adhesion of Neisseria meningitidis to Human Brain Microvascular Endothelial Cells

A Kulkarni, E Mochnáčová, P Majerova… - Frontiers in molecular …, 2020 - frontiersin.org
Neisseria adhesin A (NadA), one of the surface adhesins of Neisseria meningitides (NM),
interacts with several cell types including human brain microvascular endothelial cells …

Generating therapeutic monoclonal antibodies to complex multi-spanning membrane targets: overcoming the antigen challenge and enabling discovery strategies

R Dodd, DJ Schofield, T Wilkinson, ZT Britton - Methods, 2020 - Elsevier
Complex integral membrane proteins, which are embedded in the cell surface lipid bilayer
by multiple transmembrane spanning helices, encompass families of proteins which are …

Engineering Nanobody Targeting Cancer Stem Cells

MS Islam, V Gopalan, F Islam - Cancer Stem Cells: Basic Concept and …, 2023 - Springer
Nanobodies (Nbs) are great molecular tools that can circumvent the limitations of traditional
antibodies such as large size, low stability, slow clearance, and high immunogenicity …

In Silico Investigation of Signal Peptide Sequences to Enhance Secretion of CD44 Nanobodies Expressed in Escherichia coli

S Kavousipour, S Mohammadi… - Current …, 2021 - ingentaconnect.com
Background: The selection of a suitable signal peptide that can direct recombinant proteins
from the cytoplasm to the extracellular space is an important criterion affecting the …

Maximizing Diversity and Functionality in Human Single-Domain Antibody Phage Display Libraries

OM Gomez - 2023 - orbit.dtu.dk
Antibodies are essential proteins of our immune system, playing a critical role in defending
our bodies against various diseases. These proteins, also known as immunoglobulins …

Screening of tumor-targeting peptides for diagnosis and therapy through phage display technology

Z Song, Y Zhang, Y Zhu, M Zhang, X Liu… - Blood&Genomics, 2021 - blood-genomics.com
Phage display technology was introduced by G. Smith in 1985, which is highly effective in
the selection of affinity peptides from a library containing billions of display peptides. The …

[PDF][PDF] https://www. jbc. org/cgi/doi/10.1074/jbc. REV120. 012960 The latest version is at

RW Cheloha, TJ Harmand, C Wijne, TU Schwartz… - researchgate.net
Reagents that bind tightly and specifically to biomolecules of interest remain essential in the
exploration of biology and in their ultimate application to medicine. Besides ligands for …