Role of mTORC1 in mechanically induced increases in translation and skeletal muscle mass
CA Goodman - Journal of applied physiology, 2019 - journals.physiology.org
Skeletal muscle mass is, in part, regulated by the rate of mRNA translation (ie, protein
synthesis). The conserved serine/threonine kinase, mTOR (the mammalian/mechanistic …
synthesis). The conserved serine/threonine kinase, mTOR (the mammalian/mechanistic …
Dysregulation of TCTP in biological processes and diseases
UA Bommer, A Telerman - Cells, 2020 - mdpi.com
Translationally controlled tumor protein (TCTP), also called histamine releasing factor (HRF)
or fortilin, is a multifunctional protein present in almost all eukaryotic organisms. TCTP is …
or fortilin, is a multifunctional protein present in almost all eukaryotic organisms. TCTP is …
The translational controlled tumour protein TCTP: biological functions and regulation
UA Bommer - TCTP/tpt1-Remodeling Signaling from Stem Cell to …, 2017 - Springer
Abstract The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called
P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein …
P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein …
[HTML][HTML] The role of mTORC1 in the regulation of skeletal muscle mass
SC Bodine - Faculty Reviews, 2022 - ncbi.nlm.nih.gov
Skeletal muscle mass is a very plastic characteristic of skeletal muscle and is regulated by
signaling pathways that control the balance between anabolic and catabolic processes. The …
signaling pathways that control the balance between anabolic and catabolic processes. The …
The regulation of polyamine pathway proteins in models of skeletal muscle hypertrophy and atrophy: A potential role for mTORC1
M Tabbaa, T Ruz Gomez, DG Campelj… - … of Physiology-Cell …, 2021 - journals.physiology.org
Polyamines have been shown to be absolutely required for protein synthesis and cell
growth. The serine/threonine kinase, the mechanistic target of rapamycin complex 1 …
growth. The serine/threonine kinase, the mechanistic target of rapamycin complex 1 …
Genes whose gain or loss-of-function increases skeletal muscle mass in mice: A systematic literature review
SAJ Verbrugge, M Schönfelder, L Becker… - Frontiers in …, 2018 - frontiersin.org
Skeletal muscle mass differs greatly in mice and humans and this is partially inherited. To
identify muscle hypertrophy candidate genes we conducted a systematic review to identify …
identify muscle hypertrophy candidate genes we conducted a systematic review to identify …
A deep analysis of the proteomic and phosphoproteomic alterations that occur in skeletal muscle after the onset of immobilization
KH Lin, GM Wilson, R Blanco… - The Journal of …, 2021 - Wiley Online Library
Key points A decrease in protein synthesis plays a major role in the loss of muscle mass that
occurs in response to immobilization. In mice, immobilization leads to a rapid (within 6 h) …
occurs in response to immobilization. In mice, immobilization leads to a rapid (within 6 h) …
Role of TCTP in cell biological and disease processes
UA Bommer, T Kawakami - Cells, 2021 - mdpi.com
Translationally controlled tumor protein (TCTP), also referred to as histamine-releasing
factor (HRF) or fortilin, is a multifunctional protein, expressed in essentially all eukaryotic …
factor (HRF) or fortilin, is a multifunctional protein, expressed in essentially all eukaryotic …
TCTP protein degradation by targeting mTORC1 and signaling through S6K, Akt, and Plk1 sensitizes lung cancer cells to DNA-damaging drugs
M Jeong, MH Jeong, JE Kim, S Cho, KJ Lee, S Park… - Scientific reports, 2021 - nature.com
Translationally controlled tumor protein (TCTP) is expressed in many tissues, particularly in
human tumors. It plays a role in malignant transformation, apoptosis prevention, and DNA …
human tumors. It plays a role in malignant transformation, apoptosis prevention, and DNA …
Cellular and molecular signatures of alcohol-induced myopathy in women
BS Shenkman, OE Zinovyeva… - American Journal …, 2019 - journals.physiology.org
Alcoholic myopathy is characterized by the reduction in cross-sectional area (CSA) of
muscle fibers and impaired anabolic signaling. The goal of the current study was to …
muscle fibers and impaired anabolic signaling. The goal of the current study was to …