Metabolism and ATP levels within the oocyte and adjacent cumulus cells are associated
with quality of oocyte and optimal development of a healthy embryo. Lipid metabolism …

Mammalian oocytes and early cleavage-stage embryos are critically dependent on their
100,000 mitochondria to develop from ovulation to compacted morula stage. They rely …

Contents While much is known about the metabolism of exogenous nutrients such as
glucose, lactate, pyruvate, amino acids by oocytes and pre‐implantation mammalian …

Cardiogenesis within embryos or associated with heart repair requires stem cell
differentiation into energetically competent, contracting cardiomyocytes. While it is widely …

BACKGROUND Despite advances in ART, implantation and pregnancy rates per embryo
transfer still remain low. IVF laboratories strive to ensure that the process of handling …

STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in
embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight …

Mobilization of fatty acids from adipose tissue during metabolic stress will increase the
amount of free fatty acids in blood and follicular fluid and, thus, may affect oocyte quality. In …

In this essay, we propose that embryos express a metabolic phenotype necessarily different
from that of differentiated somatic cells and more like that of rapidly proliferating cancer cells …

Melatonin, a major hormone of the pineal gland, exerts many beneficial effects on
mitochondria. Several studies have shown that melatonin can protect against toxin‐induced …

Obesity, diabetes, and related metabolic disorders are major health issues worldwide. As
the epidemic of metabolic disorders continues, the associated medical co-morbidities …