CD123 as a therapeutic target in the treatment of hematological malignancies

U Testa, E Pelosi, G Castelli - Cancers, 2019 - mdpi.com
The interleukin-3 receptor alpha chain (IL-3Rα), more commonly referred to as CD123, is
widely overexpressed in various hematological malignancies, including acute myeloid …

Blastic plasmacytoid dendritic cell neoplasm: diagnostic criteria and therapeutical approaches

L Pagano, CG Valentini, S Grammatico… - British journal of …, 2016 - Wiley Online Library
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare haematological malignancy
derived from the precursors of plamacytoid dendritic cells, with an aggressive clinical course …

[HTML][HTML] Tagraxofusp in blastic plasmacytoid dendritic-cell neoplasm

N Pemmaraju, AA Lane, KL Sweet… - … England Journal of …, 2019 - Mass Medical Soc
Background Blastic plasmacytoid dendritic-cell neoplasm (BPDCN) is an aggressive
hematologic cancer that is caused by transformed plasmacytoid dendritic cells that …

Acute myeloid leukemia, version 3.2023, NCCN clinical practice guidelines in oncology

DA Pollyea, JK Altman, R Assi, D Bixby… - Journal of the National …, 2023 - jnccn.org
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized
by the clonal expansion of myeloid blasts in the peripheral blood, bone marrow, and/or other …

Blastic plasmacytoid dendritic cell neoplasm is dependent on BCL2 and sensitive to venetoclax

J Montero, J Stephansky, T Cai, GK Griffin… - Cancer discovery, 2017 - AACR
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic
malignancy with dismal outcomes for which no standard therapy exists. We found that …

How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?

F Garnache-Ottou, C Vidal, S Biichlé, F Renosi… - Blood …, 2019 - ashpublications.org
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive leukemia for
which we developed a nationwide network to collect data from new cases diagnosed in …

CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies

U Testa, E Pelosi, A Frankel - Biomarker research, 2014 - Springer
Recent studies indicate that abnormalities of the alpha-chain of the interleukin-3 receptor (IL-
3RA or CD123) are frequently observed in some leukemic disorders and may contribute to …

Blastic plasmacytoid dendritic cell neoplasm: a comprehensive review in pediatrics, adolescents, and young adults (AYA) and an update of novel therapies

B Cuglievan, J Connors, J He, S Khazal, S Yedururi… - Leukemia, 2023 - nature.com
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy that
can involve the bone marrow, peripheral blood, skin, lymph nodes, and the central nervous …

Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid dendritic cell neoplasm patients

AE Frankel, JH Woo, C Ahn… - Blood, The Journal …, 2014 - ashpublications.org
This is the first prospective study of treatment of patients with blastic plasmacytoid dendritic
cell neoplasm (BPDCN), an aggressive hematologic malignancy derived from plasmacytoid …

Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis

K Togami, SS Chung, V Madan, CAG Booth… - Cancer discovery, 2022 - AACR
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of
plasmacytoid dendritic cells (pDC). BPDCN occurs at least three times more frequently in …