Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Triglyceride and triglyceride-rich lipoproteins in atherosclerosis

BH Zhang, F Yin, YN Qiao, SD Guo - Frontiers in Molecular …, 2022 - frontiersin.org
Cardiovascular disease (CVD) is still the leading cause of death globally, and
atherosclerosis is the main pathological basis of CVDs. Low-density lipoprotein cholesterol …

TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis

D Huang, B Xu, LU Liu, L Wu, Y Zhu, A Ghanbarpour… - Cell metabolism, 2021 - cell.com
How amphipathic phospholipids are shuttled between the membrane bilayer remains an
essential but elusive process, particularly at the endoplasmic reticulum (ER). One prominent …

Genes and longevity of lifespan

MN Bin-Jumah, MS Nadeem, SJ Gilani… - International Journal of …, 2022 - mdpi.com
Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …

[HTML][HTML] Dietary sphingomyelin metabolism and roles in gut health and cognitive development

C Jiang, LZ Cheong, X Zhang, AH Ali, Q Jin, W Wei… - Advances in …, 2022 - Elsevier
Sphingomyelin (SM) is a widely occurring sphingolipid that is a major plasma membrane
constituent. Milk and dairy products are rich SM sources, and human milk has high SM …

Clinically relevant dose of pemafibrate, a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), lowers serum triglyceride levels by …

Z Zhang, P Diao, X Zhang, T Nakajima, T Kimura… - Biomedicines, 2022 - mdpi.com
Pemafibrate (PEM) is a novel lipid-lowering drug classified as a selective peroxisome
proliferator-activated receptor α (PPARα) modulator whose binding efficiency to PPARα is …

Involvement of ceramides in non-alcoholic fatty liver disease (Nafld) atherosclerosis (ats) development: Mechanisms and therapeutic targets

DM Tanase, EM Gosav, D Petrov, AE Jucan… - Diagnostics, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) and atherosclerosis (ATS) are worldwide known
diseases with increased incidence and prevalence. These two are driven and are …

Novel pharmaceutical and nutraceutical-based approaches for cardiovascular diseases prevention targeting atherogenic small dense LDL

J Vekic, A Zeljkovic, A Stefanovic… - Pharmaceutics, 2022 - mdpi.com
Compelling evidence supports the causative link between increased levels of low-density
lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (CVD) …

Integrative Analyses of mRNA Expression Profile Reveal SOCS2 and CISH Play Important Roles in GHR Mutation-Induced Excessive Abdominal Fat Deposition in …

G Chen, J Chen, J Wu, X Ren, L Li, S Lu… - Frontiers in …, 2021 - frontiersin.org
Sex-linked dwarf (SLD) chicken, which is caused by a recessive mutation of the growth
hormone receptor (GHR), has been widely used in the Chinese broiler industry. However, it …

Silicon as a Functional Meat Ingredient Improves Jejunal and Hepatic Cholesterol Homeostasis in a Late-Stage Type 2 Diabetes Mellitus Rat Model

M Hernández-Martín, A Garcimartín, A Bocanegra… - Foods, 2024 - mdpi.com
Silicon included in a restructured meat (RM) matrix (Si-RM) as a functional ingredient has
been demonstrated to be a potential bioactive antidiabetic compound. However, the jejunal …