Targeting IL-6 trans-signalling: past, present and future prospects
S Rose-John, BJ Jenkins, C Garbers, JM Moll… - Nature Reviews …, 2023 - nature.com
Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …
Mechanisms and disease consequences of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity
Non-alcoholic fatty liver disease (NAFLD) has emerged pandemically across the globe and
particularly affects patients with obesity and type 2 diabetes. NAFLD is a complex systemic …
particularly affects patients with obesity and type 2 diabetes. NAFLD is a complex systemic …
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan
For healthspan and lifespan, ERK, AMPK and mTORC1 represent critical pathways and
inflammation is a centrally important hallmark,,,,,–. Here we examined whether IL-11, a pro …
inflammation is a centrally important hallmark,,,,,–. Here we examined whether IL-11, a pro …
Fibrosis: from mechanisms to medicines
NC Henderson, F Rieder, TA Wynn - Nature, 2020 - nature.com
Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …
industrialized world. It has long been thought to be relentlessly progressive and irreversible …
Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)
X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …
NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications
Non-alcoholic fatty liver disease (NAFLD) is a public health problem, affecting up to a third of
the world's adult population. Several cohort studies have consistently documented that …
the world's adult population. Several cohort studies have consistently documented that …
[HTML][HTML] Current treatment paradigms and emerging therapies for NAFLD/NASH
S Raza, S Rajak, A Upadhyay, A Tewari… - Frontiers in bioscience …, 2021 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is one the fastest emerging manifestations of the
metabolic syndrome worldwide. Non-alcoholic steatohepatitis (NASH), the progressive form …
metabolic syndrome worldwide. Non-alcoholic steatohepatitis (NASH), the progressive form …
The mesenchymal context in inflammation, immunity and cancer
Mesenchymal cells are mesoderm-derived stromal cells that are best known for providing
structural support to organs, synthesizing and remodeling the extracellular matrix (ECM) and …
structural support to organs, synthesizing and remodeling the extracellular matrix (ECM) and …
Immune cells and immunotherapy for cardiac injury and repair
Cardiac injury remains a major cause of morbidity and mortality worldwide. Despite
significant advances, a full understanding of why the heart fails to fully recover function after …
significant advances, a full understanding of why the heart fails to fully recover function after …