Therapeutics are habitually characterized by short plasma half-lives and little affinity for
targeted cells. To overcome these challenges, nanoparticulate systems have entered into …

Extensive research efforts have been made and are still ongoing in the search for an ideal
anti-cancer therapy. Almost all chemotherapeutics require a carrier or vehicle, a drug …

Diverse nanosystems for use in cancer imaging and therapy have been designed and their
clinical applications have been assessed. Among a variety of materials available to fabricate …

Background PEGylated polylactide (PLA) and poly (lactic-co-glycolic acid)(PLGA)
copolymers are biodegradable polyesters, widely employed in the last decades for the …

Intelligent drug delivery systems based on nanotechnology have been widely developed
and investigated in the field of nanomedicine since they were able to maximize the …

Recently, active targeting using nanocarriers with biological ligands has emerged as a novel
strategy for improving the delivery of therapeutic and/or imaging agents to tumor cells. The …

Aims Triple negative breast cancer (TNBC) has drawn more and more attention due to its
high mitotic indices, high metastatic rate and poor prognosis. Gene therapy, especially RNA …

Even though chemotherapy stands as a standard option in the therapy of TNBC, problems
associated with it such as anemia, bone marrow suppression, immune suppression, toxic …

In recent years, PLGA micro/nano particle drug delivery systems has been widely used in
cancer treatment. According to the unique properties of PLGA, carriers of various structures …

Breast cancer therapeutic intervention continues to be ambiguous owing to the lack of
strategies for targeted transport and receptor-mediated uptake of drugs by cancer cells. In …