Subcellular organization of the cAMP signaling pathway
M Zaccolo, A Zerio, MJ Lobo, C Garland - Pharmacological reviews, 2021 - Elsevier
The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …
Phosphodiesterases in heart and vessels-From Physiology to Diseases
Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides,
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …
In vivo model with targeted cAMP biosensor reveals changes in receptor–microdomain communication in cardiac disease
JU Sprenger, RK Perera, JH Steinbrecher… - Nature …, 2015 - nature.com
Abstract 3′, 5′-cyclic adenosine monophosphate (cAMP) is an ubiquitous second
messenger that regulates physiological functions by acting in distinct subcellular …
messenger that regulates physiological functions by acting in distinct subcellular …
Intracellular β1-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility
Rationale: β1ARs (β1-adrenoceptors) exist at intracellular membranes and OCT3 (organic
cation transporter 3) mediates norepinephrine entry into cardiomyocytes. However, the …
cation transporter 3) mediates norepinephrine entry into cardiomyocytes. However, the …
Genetically encoded fluorescent biosensors for live-cell visualization of protein phosphorylation
Fluorescence-based, genetically encodable biosensors are widely used tools for real-time
analysis of biological processes. Over the last few decades, the number of available …
analysis of biological processes. Over the last few decades, the number of available …
Photoacoustic lifetime contrast between methylene blue monomers and self-quenched dimers as a model for dual-labeled activatable probes
Activatable photoacoustic probes efficiently combine the high spatial resolution and
penetration depth of ultrasound with the high optical contrast and versatility of molecular …
penetration depth of ultrasound with the high optical contrast and versatility of molecular …
Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle
M Nieves-Cintrón, VA Flores-Tamez, T Le… - Cellular and Molecular …, 2021 - Springer
Diabetes affects millions of people worldwide. This devastating disease dramatically
increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality …
increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality …
Compartmentalization of β-adrenergic signals in cardiomyocytes
YK Xiang - Circulation research, 2011 - Am Heart Assoc
Activation of adrenergic receptors (AR) represents the primary mechanism to increase
cardiac performance under stress. Activated βAR couple to Gs protein, leading to adenylyl …
cardiac performance under stress. Activated βAR couple to Gs protein, leading to adenylyl …
EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1
MJ Lobo, MD Amaral, M Zaccolo… - Journal of cell …, 2016 - journals.biologists.com
Cyclic AMP (cAMP) activates protein kinase A (PKA) but also the guanine nucleotide
exchange factor 'exchange protein directly activated by cAMP'(EPAC1; also known as …
exchange factor 'exchange protein directly activated by cAMP'(EPAC1; also known as …
Biophysical techniques for detection of cAMP and cGMP in living cells
JU Sprenger, VO Nikolaev - International journal of molecular sciences, 2013 - mdpi.com
Cyclic nucleotides cAMP and cGMP are ubiquitous second messengers which regulate
myriads of functions in virtually all eukaryotic cells. Their intracellular effects are often …
myriads of functions in virtually all eukaryotic cells. Their intracellular effects are often …