Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

A Galano, RJ Reiter - Journal of Pineal Research, 2018 - Wiley Online Library
Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …

Mitochondrial dysfunction and mitochondrial therapies in heart failure

C Wu, Z Zhang, W Zhang, X Liu - Pharmacological Research, 2022 - Elsevier
Cardiovascular diseases remain the leading cause of death worldwide in the last decade,
accompanied by immense health and economic burdens. Heart failure (HF), as the terminal …

Melatonin as a potential approach to anxiety treatment

K Repova, T Baka, K Krajcirovicova, P Stanko… - International journal of …, 2022 - mdpi.com
Anxiety disorders are the most common mental diseases. Anxiety and the associated
physical symptoms may disturb social and occupational life and increase the risk of somatic …

Evidence for the benefits of melatonin in cardiovascular disease

M Tobeiha, A Jafari, S Fadaei, SMA Mirazimi… - Frontiers in …, 2022 - frontiersin.org
The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

P Allawadhi, A Khurana, N Sayed… - Phytotherapy …, 2018 - Wiley Online Library
Heart is the most active and incumbent organ of the body, which maintains blood flow, but
due to various pathological reasons, several acute and chronic cardiac complications arise …

Effects of melatonin on cardiovascular risk factors and metabolic syndrome: a comprehensive review

M Imenshahidi, G Karimi, H Hosseinzadeh - … -Schmiedeberg's Archives of …, 2020 - Springer
Melatonin, as a neuroendocrine hormone, is produced primarily by the pineal gland.
Melatonin, a pleotropic molecule, acts as a free radical scavenger, antioxidant, and regulator …

Melatonin: the dawning of a treatment for fibrosis?

W Hu, Z Ma, S Jiang, C Fan, C Deng… - Journal of Pineal …, 2016 - Wiley Online Library
Fibrosis is a common occurrence following organ injury and failure. To date, there is no
effective treatment for this condition. Melatonin targets numerous molecular pathways, a …

Cardiovascular benefits of dietary melatonin: a myth or a reality?

Z Jiki, S Lecour, F Nduhirabandi - Frontiers in physiology, 2018 - frontiersin.org
The role of the diet as well as the impact of the dietary habits on human health and disease
is well established. Apart from its sleep regulatory effect, the indoleamine melatonin is a well …

Melatonin inhibits formation of mitochondrial permeability transition pores and improves oxidative phosphorylation of frozen-thawed ram sperm

Y Fang, C Zhao, H Xiang, X Zhao… - Frontiers in …, 2020 - frontiersin.org
Structural and functional damages to mitochondria of frozen-thawed sperm are a typical
cryoinjury, with mitochondrial permeability transition pore (MPTP) formation being the …

[HTML][HTML] Insight into the mechanism of melatonin in attenuating PCB126-induced liver injury: Resistance to ROS-dependent NETs formation to alleviate inflammation …

Y Xia, D Luo, A Xu, B Zhao, H Lin, H Yao, S Li - … and Environmental Safety, 2024 - Elsevier
Abstract 3, 3′, 4′, 4′, 5-Polychlorinated biphenyls (PCB126) is classified as a persistent
organic environmental pollutant that can cause liver damage by producing excessive …