The transition from genomics to phenomics in personalized population health
Modern health care faces several serious challenges, including an ageing population and
its inherent burden of chronic diseases, rising costs and marginal quality metrics. By …
its inherent burden of chronic diseases, rising costs and marginal quality metrics. By …
Wearable and digital devices to monitor and treat metabolic diseases
Cardiometabolic diseases are a major public-health concern owing to their increasing
prevalence worldwide. These diseases are characterized by a high degree of interindividual …
prevalence worldwide. These diseases are characterized by a high degree of interindividual …
Bacterial SNPs in the human gut microbiome associate with host BMI
Genome-wide association studies (GWASs) have provided numerous associations between
human single-nucleotide polymorphisms (SNPs) and health traits. Likewise, metagenome …
human single-nucleotide polymorphisms (SNPs) and health traits. Likewise, metagenome …
An expanded reference map of the human gut microbiome reveals hundreds of previously unknown species
The gut is the richest ecosystem of microbes in the human body and has great influence on
our health. Despite many efforts, the set of microbes inhabiting this environment is not fully …
our health. Despite many efforts, the set of microbes inhabiting this environment is not fully …
Continuous glucose monitoring and intrapersonal variability in fasting glucose
Plasma fasting glucose (FG) levels play a pivotal role in the diagnosis of prediabetes and
diabetes worldwide. Here we investigated FG values using continuous glucose monitoring …
diabetes worldwide. Here we investigated FG values using continuous glucose monitoring …
Endocrinology in the multi-omics era
Over the past decade, technological advances have enabled cost-efficient, high-throughput
analysis of different types of omics data in large human cohorts. Here, we explore insights …
analysis of different types of omics data in large human cohorts. Here, we explore insights …
Gut microbiome modulates the effects of a personalised postprandial-targeting (PPT) diet on cardiometabolic markers: a diet intervention in pre-diabetes
O Ben-Yacov, A Godneva, M Rein, S Shilo… - Gut, 2023 - gut.bmj.com
Objective To explore the interplay between dietary modifications, microbiome composition
and host metabolic responses in a dietary intervention setting of a personalised postprandial …
and host metabolic responses in a dietary intervention setting of a personalised postprandial …
[HTML][HTML] CGMap: Characterizing continuous glucose monitor data in thousands of non-diabetic individuals
Despite its rising prevalence, diabetes diagnosis still relies on measures from blood tests.
Technological advances in continuous glucose monitoring (CGM) devices introduce a …
Technological advances in continuous glucose monitoring (CGM) devices introduce a …
Genome-wide association studies and polygenic risk score phenome-wide association studies across complex phenotypes in the human phenotype project
Background Genome-wide association studies (GWASs) associate phenotypes and genetic
variants across a study cohort. GWASs require large-scale cohorts with both phenotype and …
variants across a study cohort. GWASs require large-scale cohorts with both phenotype and …
From Glucose Patterns to Health Outcomes: A Generalizable Foundation Model for Continuous Glucose Monitor Data Analysis
G Lutsker, G Sapir, A Godneva, S Shilo… - arXiv preprint arXiv …, 2024 - arxiv.org
Recent advances in self-supervised learning enabled novel medical AI models, known as
foundation models (FMs) that offer great potential for characterizing health from diverse …
foundation models (FMs) that offer great potential for characterizing health from diverse …