Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches
JF Poulin, Z Gaertner, OA Moreno-Ramos… - Trends in …, 2020 - cell.com
Dysfunctional dopamine (DA) signaling has been associated with a broad spectrum of
neuropsychiatric disorders, prompting investigations into how midbrain DA neuron …
neuropsychiatric disorders, prompting investigations into how midbrain DA neuron …
How to make a midbrain dopaminergic neuron
Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …
during recent years. This is due in part to a growing interest in regenerative medicine and …
Predictive markers guide differentiation to improve graft outcome in clinical translation of hESC-based therapy for Parkinson's disease
Stem cell treatments for neurodegenerative diseases are expected to reach clinical trials
soon. Most of the approaches currently under development involve transplantation of …
soon. Most of the approaches currently under development involve transplantation of …
Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling
JF Poulin, J Zou, J Drouin-Ouellet, KYA Kim, F Cicchetti… - Cell reports, 2014 - cell.com
Effective approaches to neuropsychiatric disorders require detailed understanding of the
cellular composition and circuitry of the complex mammalian brain. Here, we present a …
cellular composition and circuitry of the complex mammalian brain. Here, we present a …
[HTML][HTML] Development, wiring and function of dopamine neuron subtypes
O Garritsen, EY van Battum, LM Grossouw… - Nature Reviews …, 2023 - nature.com
The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …
Multi-omic profiling of the developing human cerebral cortex at the single-cell level
The cellular complexity of the human brain is established via dynamic changes in gene
expression throughout development that is mediated, in part, by the spatiotemporal activity …
expression throughout development that is mediated, in part, by the spatiotemporal activity …
Neuronal survival in the brain: neuron type-specific mechanisms
U Pfisterer, K Khodosevich - Cell death & disease, 2017 - nature.com
Neurogenic regions of mammalian brain produce many more neurons that will eventually
survive and reach a mature stage. Developmental cell death affects both embryonically …
survive and reach a mature stage. Developmental cell death affects both embryonically …
Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of
dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Rare genetic …
dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Rare genetic …
Development and differentiation of midbrain dopaminergic neuron: From bench to bedside
Parkinson's Disease (PD) is a neurodegenerative disorder affecting the motor system. It is
primarily due to substantial loss of midbrain dopamine (mDA) neurons in the substantia …
primarily due to substantial loss of midbrain dopamine (mDA) neurons in the substantia …
Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson's disease
In addition to the well-known degeneration of midbrain dopaminergic neurons, enteric
neurons can also be affected in neurodegenerative disorders such as Parkinson's disease …
neurons can also be affected in neurodegenerative disorders such as Parkinson's disease …