Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant
that seriously threatens human health and life. Due to its high reactivity, cytotoxicity and …

Cellular senescence, a characteristic sign of aging, classically refers to permanent cell
proliferation arrest and is a vital contributor to the pathogenesis of cancer and age-related …

Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD).
CS heightens inflammation, oxidative stress and apoptosis. Ergosterol is the main bioactive …

Background Aging is one of the key contributing factors for chronic obstructive pulmonary
diseases (COPD) and other chronic inflammatory lung diseases. Here, we determined how …

Introduction: Older adults are more susceptible to severe COVID-19, with increased all-
cause mortality. This has been attributed to their multimorbidity and disability. However, it …

Extracellular vesicles (EVs) have been identified as key messengers of intracellular
communication in health and disease, including the lung. EVs that can be found in …

Background COPD is associated with an abnormal lung immune response that leads to
tissue damage and remodeling of the lung, but also to systemic effects that compromise …

Chronic obstructive pulmonary disease (COPD) is recognized as a disease of accelerated
lung aging. Over the past two decades, mounting evidence suggests an accumulation of …

Cellular senescence is a state of permanent cell cycle arrest triggered by various intrinsic
and extrinsic stressors. Cellular senescence results in impaired tissue repair and …

Objective: Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory
disease of human beings characterized by not fully reversible airflow limitation. Emphysema …