Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes

MB McGuckin, J Wang, R Ghanma, N Qin… - Journal of Controlled …, 2022 - Elsevier
The poor aqueous solubility of many approved drugs and most new chemical entities poses
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …

Approved nanomedicine against diseases

Y Jia, Y Jiang, Y He, W Zhang, J Zou, KT Magar… - Pharmaceutics, 2023 - mdpi.com
Nanomedicine is a branch of medicine using nanotechnology to prevent and treat diseases.
Nanotechnology represents one of the most effective approaches in elevating a drug's …

A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing

MS Arshad, S Zafar, B Yousef, Y Alyassin, R Ali… - Advanced drug delivery …, 2021 - Elsevier
Tablets are the most widely utilized solid oral dosage forms because of the advantages of
self-administration, stability, ease of handling, transportation, and good patient compliance …

[HTML][HTML] Particle engineering in dry powders for inhalation

R Scherließ, S Bock, N Bungert, A Neustock… - European Journal of …, 2022 - Elsevier
Drug administration by inhalation is a well-established approach to treat respiratory and
systemic diseases. To deliver a drug into the lung dry powder inhalation (DPI) is an …

Bioavailability enhancement of poorly water-soluble drugs via nanocomposites: Formulation–Processing aspects and challenges

A Bhakay, M Rahman, RN Dave, E Bilgili - Pharmaceutics, 2018 - mdpi.com
Drug nanoparticles embedded in a dispersant matrix as a secondary phase, ie, drug-laden
nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and …

[HTML][HTML] Oral drug delivery strategies for development of poorly water soluble drugs in paediatric patient population

S Salunke, F O'Brien, DCT Tan, D Harris… - Advanced Drug Delivery …, 2022 - Elsevier
Selecting the appropriate formulation and solubility-enabling technology for poorly water
soluble drugs is an essential element in the development of formulations for paediatric …

Production of pure drug nanocrystals and nano co-crystals by confinement methods

F Fontana, P Figueiredo, P Zhang, JT Hirvonen… - Advanced drug delivery …, 2018 - Elsevier
The use of drug nanocrystals in the drug formulation is increasing due to the large number of
poorly water-soluble drug compounds synthetized and due to the advantages brought by the …

Particle size reduction techniques of pharmaceutical compounds for the enhancement of their dissolution rate and bioavailability

R Kumar, AK Thakur, P Chaudhari… - Journal of Pharmaceutical …, 2022 - Springer
In pharmaceutical research and development, various new chemical entities (NCE) are
found to be poorly water-soluble. Therefore, solubility enhancement, a key factor for higher …

Nanomedicines inhibiting tumor metastasis and recurrence and their clinical applications

X Kong, R Cheng, J Wang, Y Fang, KC Hwang - Nano Today, 2021 - Elsevier
Tumor metastasis and recurrence is one of the biggest problems in curing cancers. Due to
the difficulty in complete removal of the primary tumor in traditional surgeries and the poor …

Drug nanocrystals–versatile option for formulation of poorly soluble materials

L Peltonen, J Hirvonen - International journal of pharmaceutics, 2018 - Elsevier
Poor solubility of drug compounds is a great issue in drug industry today and decreasing
particle size is one efficient and simple way to overcome this challenge. Drug nanocrystals …