Triazole derivatives and their anti-tubercular activity
S Zhang, Z Xu, C Gao, QC Ren, L Chang, ZS Lv… - European journal of …, 2017 - Elsevier
Tuberculosis (TB) remains one of the most widespread and leading deadliest diseases,
threats one-third of the world's population. Although numerous efforts have been undertaken …
threats one-third of the world's population. Although numerous efforts have been undertaken …
Progress of the synthesis of condensed pyrazole derivatives (from 2010 to mid-2013)
M Li, BX Zhao - European Journal of Medicinal Chemistry, 2014 - Elsevier
Condensed pyrazole derivatives are important heterocyclic compounds due to their
excellent biological activities and have been widely applied in pharmaceutical and …
excellent biological activities and have been widely applied in pharmaceutical and …
Synthesis of pyrazolo [3, 4-d] pyrimidin-4 (5H)-ones tethered to 1, 2, 3-triazoles and their evaluation as potential anticancer agents
M Allam, AKD Bhavani, A Mudiraj, N Ranjan… - European Journal of …, 2018 - Elsevier
A series of hybrid aza heterocycles containing pyrazolo [3, 4-d] pyrimidin-4 (5 H)-ones
tethered to 1, 2, 3-triazole scaffold were synthesized from 1, 3-dipolar cycloaddition reaction …
tethered to 1, 2, 3-triazole scaffold were synthesized from 1, 3-dipolar cycloaddition reaction …
Design, synthesis and chemoinformatic studies of new thiazolopyrimidine derivatives as potent anticancer agents via phosphodiesterase-5 inhibition and apoptotic …
Abstract Inhibition of phosphodiesterase-5 (PDE5) has been validated as possible new
therapeutic approach for cancer. To further explore this concept, three series of …
therapeutic approach for cancer. To further explore this concept, three series of …
New pyrazolo [3, 4-d] pyrimidine derivatives as EGFR-TK inhibitors: design, green synthesis, potential anti-proliferative activity and P-glycoprotein inhibition
AI Hassaballah, AM AboulMagd, MM Hemdan… - RSC …, 2024 - pubs.rsc.org
In this study, four series of new pyrazolo [3, 4-d] pyrimidine derivatives were designed and
synthesized with both green and conventional methods. All the synthesized candidates were …
synthesized with both green and conventional methods. All the synthesized candidates were …
A new insight into the synthesis and biological activities of pyrazole based derivatives
This review aims to collate literature work reported by researchers (from 1994 to 2021) to
provide an overview of the available methodologies for the synthesis and diverse …
provide an overview of the available methodologies for the synthesis and diverse …
N-and s-substituted Pyrazolopyrimidines: A promising new class of potent c-Src kinase inhibitors with prominent antitumor activity
In this work, readily achievable synthetic pathways were utilized for construction of a library
of N/S analogues based on the pyrazolopyrimidine scaffold with terminal alkyl or aryl …
of N/S analogues based on the pyrazolopyrimidine scaffold with terminal alkyl or aryl …
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1-phenylpyrazolo[3,4-d]pyrimidine derivatives
A new group of 1-phenylpyrazolo [3, 4-d] pyrimidine derivatives 14a–d–21 were synthesized
from 2-(6-methyl-1-phenyl-1 H-pyrazolo [3, 4-d] pyrimidin-4-yloxy) acetohydrazide (12). All …
from 2-(6-methyl-1-phenyl-1 H-pyrazolo [3, 4-d] pyrimidin-4-yloxy) acetohydrazide (12). All …
Design and synthesis of pyrazolo [3, 4-d] pyrimidines: Nitric oxide releasing compounds targeting hepatocellular carcinoma
YAMM Elshaier, MA Shaaban, MK Abd El Hamid… - Bioorganic & Medicinal …, 2017 - Elsevier
A new series of pyrazolo [3, 4-d] pyrimidines tethered with nitric oxide (NO) producing
functionality was designed and synthesized. Sulforhodamine B (SRB) protein assay …
functionality was designed and synthesized. Sulforhodamine B (SRB) protein assay …
Design and synthesis of novel pyrazolo [3, 4-d] pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy
PDE5 targeting represents a new and promising strategy for apoptosis induction and
inhibition of tumor cell growth due to its over-expression in diverse types of human …
inhibition of tumor cell growth due to its over-expression in diverse types of human …