Selenium, originally described as a toxin, turns out to be a crucial trace element for life that
appears as selenocysteine and its dimer, selenocystine. From the point of view of drug …

The discovery and synthetic applications of novel organoselenium compounds and their
reactions proceeded rapidly during the past fifty years and such processes are now carried …

Nucleoside analogs have proven highly successful in many pharmaceutical intervention
strategies, and continued exploration of next generation structural motifs is required. Herein …

Potent and selective A3 adenosine receptor (AR) agonists were identified by the
replacement of 4′-oxo-or 4′-thionucleosides with bioisosteric selenium. Unlike previous …

Since its discovery 200 years ago, in 1817, by Jöns Jacob Berzelius (1779–1848), the
element selenium has had a rather chequered relationship with biology and medicine, an …

In search of a new template for anti-hepatitis C virus (HCV) agents, we designed and
synthesized the 2′-C-methyl-4′-selenopyrimidine and-purine nucleosides and their …

A chiral bio-based building block, prepared by the lipase-mediated desymmetrization of an
erythritol derivative, was further functionalized and then submitted to stereoselective …

To synthesize nucleoside and oligosaccharide derivatives, we often use a glycosylation
reaction to form a glycoside bond. Coupling reactions between a nucleobase and a sugar …

Abstract N 6-(3-Iodobenzyl) adenosine-5′-N-methyluronamide (1a, IB-MECA) exhibited
polypharmacological characteristics targeting A 3 adenosine receptor (AR), peroxisome …

Intrigued by the biological activity of 2′‐C‐methylribofuranosyl nucleosides, and
ribavirin/acadesine, based on the bioisosteric rationale between oxygen and selenium, we …