Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Despite
significant progress that has been made in therapies against CRC over the past decades …

Abstract Protein arginine methyltransferases 5 (PRMT5), a therapeutic target whose main
physiological function is mono-and symmetric dimethylation of arginine, has drawn …

Protein arginine methyltransferases (PRMTs) are known for their ability to catalyze
methylation of specific arginine residues in a wide variety of cellular proteins, which are …

Colorectal cancer (CRC) is one of the costliest health problems and ranks second in cancer-
related mortality in developed countries. With the aid of proteomics, many protein …

There are five fibroblast growth factor receptors (FGFRs), namely, FGFR1–FGFR5. When
FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and …

The protein arginine methyltransferase 5 (PRMT5) as the major type II arginine
methyltransferase catalyzes the mono-and symmetric dimethylation of arginine residues in …

Protein arginine methyltransferases (PRMTs) play important roles in protein methylation.
PRMT5 is the major type II arginine methyltransferase that catalyzes the transfer of two …

Oligodendrocytes (OLs) are the myelin-forming cells of the central nervous system. They are
derived from differentiation of oligodendrocyte progenitors through a process requiring cell …

Hydrogen sulfide (H2S) is involved in cancer biological processes. However, there are
several controversies concerning the role of H2S in cancer development and progression. In …