Current and emerging strategies to combat antimalarial resistance
C Rasmussen, P Alonso, P Ringwald - Expert Review of Anti …, 2022 - Taylor & Francis
Introduction Since the spread of chloroquine resistance in Plasmodium falciparum in the
1960s, recommendations have been made on how to respond to antimalarial resistance …
1960s, recommendations have been made on how to respond to antimalarial resistance …
Antimalarial drug resistance and implications for the WHO global technical strategy
Abstract Purpose of Review Five years have passed since the World Health Organization
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …
Extension of efficacy range for targeted malaria-elimination interventions due to spillover effects
Malaria-elimination interventions aim to extinguish hotspots and prevent transmission to
nearby areas. Here, we re-analyzed a cluster-randomized trial of reactive, focal interventions …
nearby areas. Here, we re-analyzed a cluster-randomized trial of reactive, focal interventions …
Pathogenicity and virulence of malaria: Sticky problems and tricky solutions
IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …
each year, concentrated in Africa and in young children, but much of the world's population …
Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria
M Mukaka, MA Onyamboko, P Olupot-Olupot… - …, 2023 - thelancet.com
Background There are no pharmacokinetic data of single low dose primaquine (SLDPQ) as
transmission blocking in African children with acute Plasmodium falciparum and glucose-6 …
transmission blocking in African children with acute Plasmodium falciparum and glucose-6 …
Plasmodium falciparum sexual conversion rates can be affected by artemisinin-based treatment in naturally infected malaria patients
HP Portugaliza, HM Natama, P Guetens… - …, 2022 - thelancet.com
Background Artemisinins (ART) are the key component of the frontline antimalarial
treatment, but their impact on Plasmodium falciparum sexual conversion rates in natural …
treatment, but their impact on Plasmodium falciparum sexual conversion rates in natural …
Progress and challenges of integrated drug efficacy surveillance for uncomplicated malaria in Thailand
P Sudathip, A Saejeng, N Khantikul, T Thongrad… - Malaria Journal, 2021 - Springer
Background Integrated drug efficacy surveillance (iDES) was formally introduced nationally
across Thailand in fiscal year 2018 (FY2018), building on a history of drug efficacy …
across Thailand in fiscal year 2018 (FY2018), building on a history of drug efficacy …
Identification of the asymptomatic Plasmodium falciparum and Plasmodium vivax gametocyte reservoir under different transmission intensities
C Koepfli, W Nguitragool, ACG de Almeida… - PLoS neglected …, 2021 - journals.plos.org
Background Understanding epidemiological variables affecting gametocyte carriage and
density is essential to design interventions that most effectively reduce malaria human-to …
density is essential to design interventions that most effectively reduce malaria human-to …
A single low dose of primaquine is safe and sufficient to reduce transmission of Plasmodium falciparum gametocytes regardless of cytochrome P450 2D6 enzyme …
Background Primaquine is a pro-drug and its active metabolite is potent against mature
Plasmodium falciparum gametocytes. Primaquine is metabolized by a highly polymorphic …
Plasmodium falciparum gametocytes. Primaquine is metabolized by a highly polymorphic …
Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data
Abstract Background In 2012, the World Health Organization (WHO) recommended single
low-dose (SLD, 0.25 mg/kg) primaquine to be added as a Plasmodium (P.) falciparum …
low-dose (SLD, 0.25 mg/kg) primaquine to be added as a Plasmodium (P.) falciparum …