Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal
function that could replace creatinine. Indeed, the concentration of cystatin C is mainly …

Serum cystatin C has been proposed as a kidney biomarker to inform drug dosing. We
conducted a systematic review to synthesize available data for the association between …

ABSTRACT A pharmacokinetic-pharmacodynamic (PKPD) model that characterizes the full
time course of in vitro time-kill curve experiments of antibacterial drugs was here evaluated …

Objectives Staphylococcus aureus osteomyelitis often develops to chronicity despite
antimicrobial treatments that have been found to be susceptible in in vitro tests. The complex …

There is little data available to guide amoxicillin-clavulanic acid dosing in critically ill
children. The primary objective of this study was to investigate the pharmacokinetics of both …

Objectives To investigate the population pharmacokinetics of cefuroxime in critically ill
patients. Methods In this observational pharmacokinetic study, multiple blood samples were …

Cefuroxime belongs to the second generation of cephalosporin antibiotics and is classified
as a β-lactam agent. Cefuroxime was approved by the US Food and Drug Administration …

Intravenous (IV) cefuroxime and cefazolin are used prophylactically in caesarean sections
(CS). Currently, there are concerns regarding sub-optimal dosing in obese pregnant women …

The objective of the present study was to review the available pharmacokinetic evidence for
the utility of cystatin C (CysC) as a marker of renal function to predict the dose of renally …

Effective concentrations of antibiotics in brain tissue are essential for antimicrobial therapy of
brain infections. However, data concerning cerebral penetration properties of antibiotics for …