For half a century, the dominant paradigm in psychotherapy research has been to develop
syndrome-specific treatment protocols for hypothesized but unproved latent disease entities …

Background Depression and anxiety are the most frequent indication for which
antidepressants are prescribed. Long‐term antidepressant use is driving much of the …

This chapter sets out the current status of the evidence-base for the efficacy and
effectiveness of psychological therapies. First, methods for eliciting and synthesizing …

Background Many clinical trials have assessed treatments for depressive disorders and
bipolar depression. However, whether, and which, assessed outcome domains really matter …

The aim of this article is to discuss the validity of relapse prevention trials and the issue of
withdrawal confounding in these trials. Recommendations for long-term antidepressant …

Abstract Background Public Health England has recommended that services be put in place
to support people who choose to withdraw from antidepressants because of a current gap …

Uncertainty regarding which psychological mechanisms are fundamental in mediating SSRI
treatment outcomes and wide-ranging variability in their efficacy has raised more questions …

Objective New treatment options for depression are warranted, due to high recurrence rates.
Recent research indicates benefits of heart rate variability biofeedback (HRVBF) on …

Previous research suggests that people may develop stronger causal illusions when the
existence of a causal relationship is consistent with their prior beliefs. In the present study …

Inflammation can play a role in the pathophysiology of depression, and specific types of
antidepressants may have inflammatory or anti-inflammatory properties. Furthermore …