Histamine and its receptors (H1R–H4R) play a crucial and significant role in the
development of various allergic diseases. Mast cells are multifunctional bone marrow …

Considerable evidence has been collected indicating that histamine can modulate
proliferation of different normal and malignant cells. High histamine biosynthesis and …

G protein-coupled receptors (GPCRs) are a family of cell-surface proteins that play critical
roles in regulating a variety of pathophysiological processes and thus are targeted by almost …

Histamine plays important roles in inflammation and nervous irritability in allergic disorders,
including atopic dermatitis (AD). It has been shown to regulate the expression of pruritic …

Cancer is the second leading cause of death globally and its incidence and mortality are
rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells …

The identification of histamine H3 (H3R) and H4 (H4R) receptors some years ago revived
interest in histamine research and exposed attractive perspectives for the potential …

During the last decade, the identification of a number of novel drug targets led to the
development of promising new compounds which are currently under evaluation for their …

The central histaminergic actions are mediated by H1, H2, H3 and H4 receptors. The
histamine H3 receptor regulates the release of histamine and a number of other …

The histamine H4 receptor (H4R) plays key role in immune cell function and is a highly
valued target for treating allergic and inflammatory diseases. However, structural information …

A visible-light-induced synthesis of 3-acylindoles from simple indoles and α-oxo acids at
room temperature has been discovered. The reaction tolerates a wide range of functional …