This review covering literature reports from the beginning of this century to 2016 describes
the synthetic pathways, the antitumor activity, the structure-activity relationship and …

Among all heterocycles, the triazine scaffold occupies a prominent position, possessing a
broad range of biological activities. Triazine is found in many potent biologically active …

Purines can be considered as the most ubiquitous and functional N-heterocyclic compounds
in nature. Structural modifications of natural purines, particularly using isosteric ring systems …

Tubulin inhibitors are effective anticancer agents, however, there are many limitations to the
use of available tubulin inhibitors in the clinic, such as multidrug resistance, severe side …

Highlights•Pyrazolotriazine is as an attractive scaffold for drug design development.•
Biological activity (in vitro and in vivo) of these derivatives are reviewed.•The SAR studies …

Privileged Scaffolds or Promiscuous Binders: A Glance of Pyrrolo[2,1-f][1,2,4]tria- zines and
Related Bridgehead Nitrogen Hetero Page 1 Send Orders of Reprints at bspsaif@emirates.net.ae …

A new photocatalyst-free visible-light-enhanced strategy for the synthesis of pyrazolo [1, 5-
a][1, 3, 5] triazine-2, 4-diamines via the formation of electron donor–acceptor (EDA) …

1, 3, 5-Triazine and azole can interact with various therapeutic targets, and their derivatives
possess promising in vitro and in vivo anticancer activity. Hybrid molecules have the …

A series of 2-imino-2 H-chromen-3-yl-1, 3, 5-triazine compounds 5–12, which are namely
hybrids of 2, 4-diamino-1, 3, 5-triazines and 2-imino-coumarins, was synthesized by reacting …

A series of 2, 6, 9-trisubstituted purine derivatives have been synthesized and investigated
for their potential role as antitumor agents. Twelve compounds were obtained by a three …