Oxidative stress and antioxidants in neurodegenerative disorders
EO Olufunmilayo, MB Gerke-Duncan, RMD Holsinger - Antioxidants, 2023 - mdpi.com
Neurodegenerative disorders constitute a substantial proportion of neurological diseases
with significant public health importance. The pathophysiology of neurodegenerative …
with significant public health importance. The pathophysiology of neurodegenerative …
A biological classification of Huntington's disease: the Integrated Staging System
SJ Tabrizi, S Schobel, EC Gantman… - The Lancet …, 2022 - thelancet.com
The current research paradigm for Huntington's disease is based on participants with overt
clinical phenotypes and does not address its pathophysiology nor the biomarker changes …
clinical phenotypes and does not address its pathophysiology nor the biomarker changes …
[HTML][HTML] Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease
DK Wilton, K Mastro, MD Heller, FW Gergits… - Nature medicine, 2023 - nature.com
Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …
Calcium signaling and molecular mechanisms underlying neurodegenerative diseases
Abstract Calcium (Ca 2+) is a ubiquitous second messenger that regulates various activities
in eukaryotic cells. Especially important role calcium plays in excitable cells. Neurons …
in eukaryotic cells. Especially important role calcium plays in excitable cells. Neurons …
A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease
Chaperones are central to the proteostasis network (PN) and safeguard the proteome from
misfolding, aggregation, and proteotoxicity. We categorized the human chaperome of 332 …
misfolding, aggregation, and proteotoxicity. We categorized the human chaperome of 332 …
Within-subject template estimation for unbiased longitudinal image analysis
Longitudinal image analysis has become increasingly important in clinical studies of normal
aging and neurodegenerative disorders. Furthermore, there is a growing appreciation of the …
aging and neurodegenerative disorders. Furthermore, there is a growing appreciation of the …
Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month …
SJ Tabrizi, RI Scahill, G Owen, A Durr… - The Lancet …, 2013 - thelancet.com
Background TRACK-HD is a multinational prospective observational study of Huntington's
disease (HD) that examines clinical and biological findings of disease progression in …
disease (HD) that examines clinical and biological findings of disease progression in …
Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study
Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin
gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis …
gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis …
Huntington's disease: from molecular pathogenesis to clinical treatment
CA Ross, SJ Tabrizi - The Lancet Neurology, 2011 - thelancet.com
Huntington's disease is a progressive, fatal, neurodegenerative disorder caused by an
expanded CAG repeat in the huntingtin gene, which encodes an abnormally long …
expanded CAG repeat in the huntingtin gene, which encodes an abnormally long …
Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset
B McAllister, J Donaldson, CS Binda, S Powell… - Nature …, 2022 - nature.com
The age at onset of motor symptoms in Huntington's disease (HD) is driven by HTT CAG
repeat length but modified by other genes. In this study, we used exome sequencing of 683 …
repeat length but modified by other genes. In this study, we used exome sequencing of 683 …