Uric acid (UA) is the end product of purine nucleotide metabolism in the human body.
Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and …

Increased serum uric acid (SUA) levels are commonly seen in patients with metabolic
syndrome and are widely accepted as risk factors for hypertension, gout, non-alcoholic fatty …

Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome,
but its relationship to kidney disease, cardiovascular disease, and diabetes remains …

Uric acid is synthesized mainly in the liver, intestines and the vascular endothelium as the
end product of an exogenous pool of purines, and endogenously from damaged, dying and …

High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …

Inflammation, a process intimately linked to renal disease, can be defined as a complex
network of interactions between renal parenchymal cells and resident immune cells, such as …

Acne vulgaris is an epidemic inflammatory disease of the human sebaceous follicle and
represents the most common skin disease affecting about 85% of adolescents in …

Hyperuricaemia is common among patients with chronic kidney disease (CKD), and
increases in severity with the deterioration of kidney function. Although existing guidelines …

Inflammasomes are intracellular multiprotein signaling platforms that initiate inflammatory
responses in response to pathogens and cellular damage. Active inflammasomes induce …

The association between increased serum urate and hypertension has been a subject of
intense controversy. Extracellular uric acid drives uric acid deposition in gout, kidney stones …