Background Randomization is the foundation of any clinical trial involving treatment
comparison. It helps mitigate selection bias, promotes similarity of treatment groups with …

Adaptive Designs for Sequential Treatment Allocation presents a rigorous theoretical
treatment of the results and mathematical foundation of adaptive design theory. The book …

Various restricted randomization procedures are available to achieve equal (1: 1) allocation
in a randomized clinical trial. However, for some procedures, there is a nonnegligible …

This book aids in identifying when to apply adaptive randomization designs in practice.
Featuring contributions from statisticians, clinical trialists, and subject-matter experts in …

Abstract The Neyman Allocation is used in many papers on experimental design, which
typically assume that researchers have access to large pilot studies. This may be unrealistic …

The present paper deals with the problem of designing randomized multiarm clinical trials
for treatment comparisons in order to achieve a suitable trade-off among inferential precision …

The aim of this paper is to analyze the impact of response-adaptive randomization rules for
normal response trials intended to test the superiority of one of two available treatments …

We investigate the value of a two-armed Bayesian response adaptive randomization (RAR)
design to investigate early preterm birth rates of high versus low dose of docosahexaenoic …

Efron's biased coin design is a restricted randomization procedure that has very favorable
balancing properties, yet it is fully randomized, in that subjects are always randomized to …

Despite the widespread use of equal randomization in clinical trials, response-adaptive
randomization has attracted considerable interest. There is typically a prerun of equal …